[Music]
[Music] [Applause]
may I show offense how many of you heard
may I show offense how many of you heard about precision medicine sad listen you
about precision medicine sad listen you
about precision medicine sad listen you want but do you know how many of you
want but do you know how many of you
want but do you know how many of you heard about Barack Obama everyone okay
heard about Barack Obama everyone okay
heard about Barack Obama everyone okay for information precision medicine and
for information precision medicine and
for information precision medicine and medicine initiatives was initiated by
medicine initiatives was initiated by
medicine initiatives was initiated by Barack Obama in 2015 but how many of us
Barack Obama in 2015 but how many of us
Barack Obama in 2015 but how many of us really understand this precision
really understand this precision
really understand this precision medicine and how does this approach
medicine and how does this approach
medicine and how does this approach actually help mankind and contribute to
actually help mankind and contribute to
actually help mankind and contribute to many of the patients we know that
many of the patients we know that
many of the patients we know that position medicines is a mouthful okay
position medicines is a mouthful okay
position medicines is a mouthful okay according to the Center for Disease
according to the Center for Disease
according to the Center for Disease Control and Prevention precision
Control and Prevention precision
Control and Prevention precision medicine is an approach for protecting
medicine is an approach for protecting
medicine is an approach for protecting health and treating diseases taking into
health and treating diseases taking into
health and treating diseases taking into account of persons genetics surrounding
account of persons genetics surrounding
account of persons genetics surrounding land stars and also their environment so
land stars and also their environment so
land stars and also their environment so now this particular intervention
now this particular intervention
now this particular intervention actually takes into account of genes and
actually takes into account of genes and
actually takes into account of genes and also their environment compared to the
also their environment compared to the
also their environment compared to the conventional approach which is one size
conventional approach which is one size
conventional approach which is one size that fits all so if you look at the the
that fits all so if you look at the the
that fits all so if you look at the the charge here many reports are mentioned
charge here many reports are mentioned
charge here many reports are mentioned that with the conventional approach that
that with the conventional approach that
that with the conventional approach that one size fits all is only benefits 20%
one size fits all is only benefits 20%
one size fits all is only benefits 20% of the population where else if we
of the population where else if we
of the population where else if we stratify the population based on their
stratify the population based on their
stratify the population based on their genetic makeup then you were able to see
genetic makeup then you were able to see
genetic makeup then you were able to see that these population then will benefit
that these population then will benefit
that these population then will benefit from different kind of treatment their
from different kind of treatment their
from different kind of treatment their tailoring to their particular genetic
tailoring to their particular genetic
tailoring to their particular genetic makeup so to elaborate more on this
makeup so to elaborate more on this
makeup so to elaborate more on this precision medicine
precision medicine
precision medicine I will think cancer
I will think cancer
I will think cancer act like an example so why cancer cancer
act like an example so why cancer cancer
act like an example so why cancer cancer is a very complex diseases and it can
is a very complex diseases and it can
is a very complex diseases and it can caused by many factors such as
caused by many factors such as
caused by many factors such as environment lifestyle genetics
environment lifestyle genetics
environment lifestyle genetics infections agents such as HPV and also
infections agents such as HPV and also
infections agents such as HPV and also epigenetics that’s why precision
epigenetics that’s why precision
epigenetics that’s why precision medicine is the best approaches for
medicine is the best approaches for
medicine is the best approaches for these typical complex diseases so we
these typical complex diseases so we
these typical complex diseases so we know that cancer is a second Malia’s
know that cancer is a second Malia’s
know that cancer is a second Malia’s diseases in the world why and if you
diseases in the world why and if you
diseases in the world why and if you look at this cartoon eeeh so if you look
look at this cartoon eeeh so if you look
look at this cartoon eeeh so if you look at cancer we always realize that it’s
at cancer we always realize that it’s
at cancer we always realize that it’s only the changes of the surface that one
only the changes of the surface that one
only the changes of the surface that one we can see only the lung but did you
we can see only the lung but did you
we can see only the lung but did you know that there is underlying cause
know that there is underlying cause
know that there is underlying cause apart from the others environment your
apart from the others environment your
apart from the others environment your race or your history there also
race or your history there also
race or your history there also something beneath these cancer cells
something beneath these cancer cells
something beneath these cancer cells that’s what we call gene that control
that’s what we call gene that control
that’s what we call gene that control the progressions of these cancers and
the progressions of these cancers and
the progressions of these cancers and also that it will determine what type of
also that it will determine what type of
also that it will determine what type of treatment that is designed for this
treatment that is designed for this
treatment that is designed for this particular cancer so we now know that
particular cancer so we now know that
particular cancer so we now know that each of these cancer cells actually
each of these cancer cells actually
each of these cancer cells actually control by a specific gene and this gene
control by a specific gene and this gene
control by a specific gene and this gene is none other than your own gene they
is none other than your own gene they
is none other than your own gene they actually mutated so the word mutation
actually mutated so the word mutation
actually mutated so the word mutation air refer to an alteration of the gene
air refer to an alteration of the gene
air refer to an alteration of the gene sequences that caused by radiation
sequences that caused by radiation
sequences that caused by radiation environment and also surrounding and
environment and also surrounding and
environment and also surrounding and also chemicals so you look at the chart
also chemicals so you look at the chart
also chemicals so you look at the chart here so mutation on the particular
here so mutation on the particular
here so mutation on the particular sequences can cascade it down and a fang
sequences can cascade it down and a fang
sequences can cascade it down and a fang the translation of a minuses and also
the translation of a minuses and also
the translation of a minuses and also the end product so if you look at the
the end product so if you look at the
the end product so if you look at the word here are uses as an analogy I have
word here are uses as an analogy I have
word here are uses as an analogy I have a cat this is not proofreading if you
a cat this is not proofreading if you
a cat this is not proofreading if you look at it if
look at it if
look at it if you just changed a letter so it means
you just changed a letter so it means
you just changed a letter so it means the meaning change similarly to our own
the meaning change similarly to our own
the meaning change similarly to our own gene even a single letter change in a
gene even a single letter change in a
gene even a single letter change in a specific area of that particular gene is
specific area of that particular gene is
specific area of that particular gene is actually drive the cells to behave
actually drive the cells to behave
actually drive the cells to behave differently so now our body not only
differently so now our body not only
differently so now our body not only covers by only one segment of gene
covers by only one segment of gene
covers by only one segment of gene million of it so can you imagine so many
million of it so can you imagine so many
million of it so can you imagine so many records or data shown that if we detain
records or data shown that if we detain
records or data shown that if we detain this mutation earlier before the disease
this mutation earlier before the disease
this mutation earlier before the disease progression
progression
progression there are about 70% survival as compared
there are about 70% survival as compared
there are about 70% survival as compared to less fish and many of us know that if
to less fish and many of us know that if
to less fish and many of us know that if you detect the cancer late then it was
you detect the cancer late then it was
you detect the cancer late then it was spread so it is not about what type of
spread so it is not about what type of
spread so it is not about what type of treatment it does but it depends on how
treatment it does but it depends on how
treatment it does but it depends on how sensitive an approach to actually detect
sensitive an approach to actually detect
sensitive an approach to actually detect this cancer we all understand that maybe
this cancer we all understand that maybe
this cancer we all understand that maybe is the jargon so we understand that
is the jargon so we understand that
is the jargon so we understand that there are many modalities available to
there are many modalities available to
there are many modalities available to actually look into these cancers namely
actually look into these cancers namely
actually look into these cancers namely mammography gastro endoscopy low-dose CT
mammography gastro endoscopy low-dose CT
mammography gastro endoscopy low-dose CT all these techniques in only looking at
all these techniques in only looking at
all these techniques in only looking at the surfaces of the cancers but what
the surfaces of the cancers but what
the surfaces of the cancers but what that this modalities means is all those
that this modalities means is all those
that this modalities means is all those unknown cases the caused by the gene
unknown cases the caused by the gene
unknown cases the caused by the gene beneath these cancer cells so now in the
beneath these cancer cells so now in the
beneath these cancer cells so now in the field of molecular diagnostics what we
field of molecular diagnostics what we
field of molecular diagnostics what we need on what do we look is the
need on what do we look is the
need on what do we look is the particular changes I mentioned the
particular changes I mentioned the
particular changes I mentioned the mutation but this is not only the area
mutation but this is not only the area
mutation but this is not only the area that we cover but we know we also look
that we cover but we know we also look
that we cover but we know we also look into the details of how sensitive an
into the details of how sensitive an
into the details of how sensitive an approach that can detain as low as a
approach that can detain as low as a
approach that can detain as low as a single gene that is mutated in the cells
single gene that is mutated in the cells
single gene that is mutated in the cells so thanks to the interventions of
so thanks to the interventions of
so thanks to the interventions of biomedical scientists and all these
biomedical scientists and all these
biomedical scientists and all these engineers there are a lot of
engineers there are a lot of
engineers there are a lot of sophisticated tools such as next-gen
sophisticated tools such as next-gen
sophisticated tools such as next-gen sequencing digital PCR
sequencing digital PCR
sequencing digital PCR name it so many they actually help us to
name it so many they actually help us to
name it so many they actually help us to detain these particular cells at the
detain these particular cells at the
detain these particular cells at the genetic level so now just to replace
genetic level so now just to replace
genetic level so now just to replace that the precision medicines is not a
that the precision medicines is not a
that the precision medicines is not a traditional approach it is multi
traditional approach it is multi
traditional approach it is multi modalities or multi multi concepts which
modalities or multi multi concepts which
modalities or multi multi concepts which integrated the genes the treatment
integrated the genes the treatment
integrated the genes the treatment target treatment and also the cells and
target treatment and also the cells and
target treatment and also the cells and what most interesting now in the very
what most interesting now in the very
what most interesting now in the very near future you will see they will
near future you will see they will
near future you will see they will incorporate the immune which is your
incorporate the immune which is your
incorporate the immune which is your combat system in your body so when you
combat system in your body so when you
combat system in your body so when you look at molecular approaches especially
look at molecular approaches especially
look at molecular approaches especially the Diagnostics this now we realize that
the Diagnostics this now we realize that
the Diagnostics this now we realize that through these molecular approaches we
through these molecular approaches we
through these molecular approaches we can define and identify these mutated
can define and identify these mutated
can define and identify these mutated genes where is located because of the
genes where is located because of the
genes where is located because of the amount of these techniques previously
amount of these techniques previously
amount of these techniques previously reclassifying or the clinician
reclassifying or the clinician
reclassifying or the clinician classified cancer based on a particular
classified cancer based on a particular
classified cancer based on a particular site which is breast cancer liver cancer
site which is breast cancer liver cancer
site which is breast cancer liver cancer kidney cancer but with the amounts ‘men
kidney cancer but with the amounts ‘men
kidney cancer but with the amounts ‘men of the molecular diagnostics now the
of the molecular diagnostics now the
of the molecular diagnostics now the approach allowed the clinicians to
approach allowed the clinicians to
approach allowed the clinicians to redefine and reclassify
redefine and reclassify
redefine and reclassify these particular answer based on the
these particular answer based on the
these particular answer based on the particular mutation such as listed on my
particular mutation such as listed on my
particular mutation such as listed on my left so with this particular mutation
left so with this particular mutation
left so with this particular mutation now and thanks to the scientists that
now and thanks to the scientists that
now and thanks to the scientists that have developed a certain compounds or
have developed a certain compounds or
have developed a certain compounds or certain drugs to address this particular
certain drugs to address this particular
certain drugs to address this particular mutation so let’s look at the particular
mutation so let’s look at the particular
mutation so let’s look at the particular normal cell how is actually derived to
normal cell how is actually derived to
normal cell how is actually derived to become cancerous and subsequent how that
become cancerous and subsequent how that
become cancerous and subsequent how that these particular treatment confer a
these particular treatment confer a
these particular treatment confer a resistance e on these particular cancer
resistance e on these particular cancer
resistance e on these particular cancer cells so we realize that in normal cells
cells so we realize that in normal cells
cells so we realize that in normal cells undergoing the casino genesis due to
undergoing the casino genesis due to
undergoing the casino genesis due to mutation the tumors will form okay so
mutation the tumors will form okay so
mutation the tumors will form okay so now just now i highlighted that there
now just now i highlighted that there
now just now i highlighted that there are some treatments to
are some treatments to
are some treatments to the mutation correct so the mutation
the mutation correct so the mutation
the mutation correct so the mutation will address and we’ll treat these
will address and we’ll treat these
will address and we’ll treat these tumors however in this lump of tumors
tumors however in this lump of tumors
tumors however in this lump of tumors there are some portion of the cells will
there are some portion of the cells will
there are some portion of the cells will milk it again to confirm resistance
milk it again to confirm resistance
milk it again to confirm resistance these are all cells they need to survive
these are all cells they need to survive
these are all cells they need to survive is the evolution so some of these cells
is the evolution so some of these cells
is the evolution so some of these cells remain will undergo system resistant
remain will undergo system resistant
remain will undergo system resistant mutation and what next that these
mutation and what next that these
mutation and what next that these mutated cells will flare off become
mutated cells will flare off become
mutated cells will flare off become another resistant tumors but what the
another resistant tumors but what the
another resistant tumors but what the drugs available now you will see that
drugs available now you will see that
drugs available now you will see that there are many generations of drugs
there are many generations of drugs
there are many generations of drugs targeted therapy not to address the
targeted therapy not to address the
targeted therapy not to address the initiatives but also the resistance
initiatives but also the resistance
initiatives but also the resistance tumors thanks to the molecular
tumors thanks to the molecular
tumors thanks to the molecular diagnostic approaches you can then
diagnostic approaches you can then
diagnostic approaches you can then differentiate the initiative er to the
differentiate the initiative er to the
differentiate the initiative er to the one resistant so this is not something
one resistant so this is not something
one resistant so this is not something that is in the story but it is something
that is in the story but it is something
that is in the story but it is something that’s available so you can see that
that’s available so you can see that
that’s available so you can see that there are many drugs available to
there are many drugs available to
there are many drugs available to address this type of alteration and you
address this type of alteration and you
address this type of alteration and you will see that the next line there are
will see that the next line there are
will see that the next line there are many ongoing improved generations of
many ongoing improved generations of
many ongoing improved generations of drugs to address this resistance
drugs to address this resistance
drugs to address this resistance mutation or resistance cells so if you
mutation or resistance cells so if you
mutation or resistance cells so if you look at the current modalities where you
look at the current modalities where you
look at the current modalities where you just look at the cells alone you will be
just look at the cells alone you will be
just look at the cells alone you will be able to see that the cells mutation of
able to see that the cells mutation of
able to see that the cells mutation of the gene however with more likely
the gene however with more likely
the gene however with more likely dynasty you need to take out the cells
dynasty you need to take out the cells
dynasty you need to take out the cells and then digest and get the DNA and
and then digest and get the DNA and
and then digest and get the DNA and subsequently detect the mutation and of
subsequently detect the mutation and of
subsequently detect the mutation and of course with that you’ll be able to treat
course with that you’ll be able to treat
course with that you’ll be able to treat the particular cancer so because of the
the particular cancer so because of the
the particular cancer so because of the advancement of the molecular diagnostics
advancement of the molecular diagnostics
advancement of the molecular diagnostics now it is not that it is has been
now it is not that it is has been
now it is not that it is has been incorporated into the normal schematic
incorporated into the normal schematic
incorporated into the normal schematic journeys of a patient you will see that
journeys of a patient you will see that
journeys of a patient you will see that here the molecular diagnosis now looking
here the molecular diagnosis now looking
here the molecular diagnosis now looking at
at
at the gene segment will assist the
the gene segment will assist the
the gene segment will assist the clinicians to make that decision upon a
clinicians to make that decision upon a
clinicians to make that decision upon a particular treatment and also is used as
particular treatment and also is used as
particular treatment and also is used as for disease progressions monitoring so
for disease progressions monitoring so
for disease progressions monitoring so again thanks to the development of the
again thanks to the development of the
again thanks to the development of the equipment and the sensitivity this is
equipment and the sensitivity this is
equipment and the sensitivity this is now I mentioned about one particular
now I mentioned about one particular
now I mentioned about one particular site detection so now there is a lot of
site detection so now there is a lot of
site detection so now there is a lot of modalities thanks to like next gene
modalities thanks to like next gene
modalities thanks to like next gene sequencing you’ll be able to see that at
sequencing you’ll be able to see that at
sequencing you’ll be able to see that at one time you’ll be able to see different
one time you’ll be able to see different
one time you’ll be able to see different mutation at different cells at one time
mutation at different cells at one time
mutation at different cells at one time so what benefits here
so what benefits here
so what benefits here the patient will pay less and most
the patient will pay less and most
the patient will pay less and most importantly now the patient we can see
importantly now the patient we can see
importantly now the patient we can see what the butler’s cells have mutated and
what the butler’s cells have mutated and
what the butler’s cells have mutated and where does this mutation on the gene
where does this mutation on the gene
where does this mutation on the gene goes into different site of the
goes into different site of the
goes into different site of the particular organs so I have prepared a
particular organs so I have prepared a
particular organs so I have prepared a particular video to show you that it is
particular video to show you that it is
particular video to show you that it is not this but composition medicine is not
not this but composition medicine is not
not this but composition medicine is not something high but it is true not only
something high but it is true not only
something high but it is true not only happens in the US or the Western we have
happens in the US or the Western we have
happens in the US or the Western we have a very own patients who actually benefit
a very own patients who actually benefit
a very own patients who actually benefit from this treatment my name is Linda
from this treatment my name is Linda
from this treatment my name is Linda balls I’m 87 years old I like to listen
balls I’m 87 years old I like to listen
balls I’m 87 years old I like to listen a lot of music I also love gardening and
a lot of music I also love gardening and
a lot of music I also love gardening and I’m very active member of the church
I’m very active member of the church
I’m very active member of the church basically I’m having a very interesting
basically I’m having a very interesting
basically I’m having a very interesting life end of 2015 I was sent to call to
life end of 2015 I was sent to call to
life end of 2015 I was sent to call to have a CT scan and when the result came
have a CT scan and when the result came
have a CT scan and when the result came out they thought I was suffering from
out they thought I was suffering from
out they thought I was suffering from tabula casas because of my black spots
tabula casas because of my black spots
tabula casas because of my black spots in my lungs so again they will mean to
in my lungs so again they will mean to
in my lungs so again they will mean to have a second x-ray asthma and I waited
have a second x-ray asthma and I waited
have a second x-ray asthma and I waited for a week and then it was confirmed
for a week and then it was confirmed
for a week and then it was confirmed that I have quite cancer everybody was
that I have quite cancer everybody was
that I have quite cancer everybody was shocked they would believe that I have
shocked they would believe that I have
shocked they would believe that I have this
this
this messing me a first diagnosis professor
messing me a first diagnosis professor
messing me a first diagnosis professor lund put me on this duck call Eric’s our
lund put me on this duck call Eric’s our
lund put me on this duck call Eric’s our and I was very very happy with it
and I was very very happy with it
and I was very very happy with it because the cancer marker was 200
because the cancer marker was 200
because the cancer marker was 200 something is down to 76 or something I
something is down to 76 or something I
something is down to 76 or something I can’t remember the figure and then later
can’t remember the figure and then later
can’t remember the figure and then later on and when I went for CT scan again it
on and when I went for CT scan again it
on and when I went for CT scan again it went up again so professor says well
went up again so professor says well
went up again so professor says well this drug is not suitable for you
this drug is not suitable for you
this drug is not suitable for you anymore
anymore
anymore so he took my blood test it was very
so he took my blood test it was very
so he took my blood test it was very kind of him you put him a lot of trouble
kind of him you put him a lot of trouble
kind of him you put him a lot of trouble for my case and he sent my blood to Hong
for my case and he sent my blood to Hong
for my case and he sent my blood to Hong Kong I took this new drug since April
Kong I took this new drug since April
Kong I took this new drug since April and I was so happy to hear that from my
and I was so happy to hear that from my
and I was so happy to hear that from my blood tests for the cancer marker and I
blood tests for the cancer marker and I
blood tests for the cancer marker and I took only 2 months of it and it came
took only 2 months of it and it came
took only 2 months of it and it came down to seventeen point nine which is
down to seventeen point nine which is
down to seventeen point nine which is very very good it my stew seems to be
very very good it my stew seems to be
very very good it my stew seems to be normal again
normal again
normal again and also that term the crumbs in my nose
and also that term the crumbs in my nose
and also that term the crumbs in my nose that has stopped also and the pimples in
that has stopped also and the pimples in
that has stopped also and the pimples in my head has also gone and I’m very very
my head has also gone and I’m very very
my head has also gone and I’m very very happy I read that this drug is really
happy I read that this drug is really
happy I read that this drug is really doing good for me and I’m very happy
doing good for me and I’m very happy
doing good for me and I’m very happy that everybody who looks at me say I
that everybody who looks at me say I
that everybody who looks at me say I don’t look like a cancer patient the
don’t look like a cancer patient the
don’t look like a cancer patient the doctor should give explain to them but
doctor should give explain to them but
doctor should give explain to them but the drugs do for them this is a very
the drugs do for them this is a very
the drugs do for them this is a very good example for them and just by
good example for them and just by
good example for them and just by explaining to them the drug is doing so
explaining to them the drug is doing so
explaining to them the drug is doing so good to this patient why don’t you have
good to this patient why don’t you have
good to this patient why don’t you have a try on this new drug and see don’t
a try on this new drug and see don’t
a try on this new drug and see don’t think so much and so get so depressed
think so much and so get so depressed
think so much and so get so depressed about the sickness the positive thinking
about the sickness the positive thinking
about the sickness the positive thinking is very important
so precision mesons is not a particular
so precision mesons is not a particular talking about drug it is a
talking about drug it is a
talking about drug it is a multi-dimensional concept it is about
multi-dimensional concept it is about
multi-dimensional concept it is about the drug the diagnosis and also the
the drug the diagnosis and also the
the drug the diagnosis and also the intervention so thanks to the
intervention so thanks to the
intervention so thanks to the development of all these molecular
development of all these molecular
development of all these molecular diagnostics now patients enjoy a
diagnostics now patients enjoy a
diagnostics now patients enjoy a pain-free approaches using just the
pain-free approaches using just the
pain-free approaches using just the blood you’ll be able to see a certain
blood you’ll be able to see a certain
blood you’ll be able to see a certain molecular diagnostic of the changes of
molecular diagnostic of the changes of
molecular diagnostic of the changes of these cancer cells the area that I
these cancer cells the area that I
these cancer cells the area that I research is focusing on identifying
research is focusing on identifying
research is focusing on identifying these biomarkers and also some small
these biomarkers and also some small
these biomarkers and also some small switches that control the mutations and
switches that control the mutations and
switches that control the mutations and also the progressions of cancer as
also the progressions of cancer as
also the progressions of cancer as molecular biologists I also serve to the
molecular biologists I also serve to the
molecular biologists I also serve to the hospital to identify a certain
hospital to identify a certain
hospital to identify a certain techniques which are sensitive approved
techniques which are sensitive approved
techniques which are sensitive approved and good enough to identify and screen
and good enough to identify and screen
and good enough to identify and screen on this cancer so spread your words that
on this cancer so spread your words that
on this cancer so spread your words that precision medicines is not that high is
precision medicines is not that high is
precision medicines is not that high is a reality and with that prevention is
a reality and with that prevention is
a reality and with that prevention is better than cure but some of us may
better than cure but some of us may
better than cure but some of us may over-interpreting this mutation so in
over-interpreting this mutation so in
over-interpreting this mutation so in line with the theme of TEDx Khanna that
line with the theme of TEDx Khanna that
line with the theme of TEDx Khanna that body mind and soul that body is one that
body mind and soul that body is one that
body mind and soul that body is one that the molecular diagnostics can detain the
the molecular diagnostics can detain the
the molecular diagnostics can detain the mind is what decision that you made and
mind is what decision that you made and
mind is what decision that you made and wrong decision that actually leads to
wrong decision that actually leads to
wrong decision that actually leads to your souls which is the rest in peace
your souls which is the rest in peace
your souls which is the rest in peace thank you
thank you
thank you [Applause]
[Applause]
[Applause] [Music]
[Music] [Applause]
may I show offense how many of you heard
may I show offense how many of you heard about precision medicine sad listen you
about precision medicine sad listen you
about precision medicine sad listen you want but do you know how many of you
want but do you know how many of you
want but do you know how many of you heard about Barack Obama everyone okay
heard about Barack Obama everyone okay
heard about Barack Obama everyone okay for information precision medicine and
for information precision medicine and
for information precision medicine and medicine initiatives was initiated by
medicine initiatives was initiated by
medicine initiatives was initiated by Barack Obama in 2015 but how many of us
Barack Obama in 2015 but how many of us
Barack Obama in 2015 but how many of us really understand this precision
really understand this precision
really understand this precision medicine and how does this approach
medicine and how does this approach
medicine and how does this approach actually help mankind and contribute to
actually help mankind and contribute to
actually help mankind and contribute to many of the patients we know that
many of the patients we know that
many of the patients we know that position medicines is a mouthful okay
position medicines is a mouthful okay
position medicines is a mouthful okay according to the Center for Disease
according to the Center for Disease
according to the Center for Disease Control and Prevention precision
Control and Prevention precision
Control and Prevention precision medicine is an approach for protecting
medicine is an approach for protecting
medicine is an approach for protecting health and treating diseases taking into
health and treating diseases taking into
health and treating diseases taking into account of persons genetics surrounding
account of persons genetics surrounding
account of persons genetics surrounding land stars and also their environment so
land stars and also their environment so
land stars and also their environment so now this particular intervention
now this particular intervention
now this particular intervention actually takes into account of genes and
actually takes into account of genes and
actually takes into account of genes and also their environment compared to the
also their environment compared to the
also their environment compared to the conventional approach which is one size
conventional approach which is one size
conventional approach which is one size that fits all so if you look at the the
that fits all so if you look at the the
that fits all so if you look at the the charge here many reports are mentioned
charge here many reports are mentioned
charge here many reports are mentioned that with the conventional approach that
that with the conventional approach that
that with the conventional approach that one size fits all is only benefits 20%
one size fits all is only benefits 20%
one size fits all is only benefits 20% of the population where else if we
of the population where else if we
of the population where else if we stratify the population based on their
stratify the population based on their
stratify the population based on their genetic makeup then you were able to see
genetic makeup then you were able to see
genetic makeup then you were able to see that these population then will benefit
that these population then will benefit
that these population then will benefit from different kind of treatment their
from different kind of treatment their
from different kind of treatment their tailoring to their particular genetic
tailoring to their particular genetic
tailoring to their particular genetic makeup so to elaborate more on this
makeup so to elaborate more on this
makeup so to elaborate more on this precision medicine
precision medicine
precision medicine I will think cancer
I will think cancer
I will think cancer act like an example so why cancer cancer
act like an example so why cancer cancer
act like an example so why cancer cancer is a very complex diseases and it can
is a very complex diseases and it can
is a very complex diseases and it can caused by many factors such as
caused by many factors such as
caused by many factors such as environment lifestyle genetics
environment lifestyle genetics
environment lifestyle genetics infections agents such as HPV and also
infections agents such as HPV and also
infections agents such as HPV and also epigenetics that’s why precision
epigenetics that’s why precision
epigenetics that’s why precision medicine is the best approaches for
medicine is the best approaches for
medicine is the best approaches for these typical complex diseases so we
these typical complex diseases so we
these typical complex diseases so we know that cancer is a second Malia’s
know that cancer is a second Malia’s
know that cancer is a second Malia’s diseases in the world why and if you
diseases in the world why and if you
diseases in the world why and if you look at this cartoon eeeh so if you look
look at this cartoon eeeh so if you look
look at this cartoon eeeh so if you look at cancer we always realize that it’s
at cancer we always realize that it’s
at cancer we always realize that it’s only the changes of the surface that one
only the changes of the surface that one
only the changes of the surface that one we can see only the lung but did you
we can see only the lung but did you
we can see only the lung but did you know that there is underlying cause
know that there is underlying cause
know that there is underlying cause apart from the others environment your
apart from the others environment your
apart from the others environment your race or your history there also
race or your history there also
race or your history there also something beneath these cancer cells
something beneath these cancer cells
something beneath these cancer cells that’s what we call gene that control
that’s what we call gene that control
that’s what we call gene that control the progressions of these cancers and
the progressions of these cancers and
the progressions of these cancers and also that it will determine what type of
also that it will determine what type of
also that it will determine what type of treatment that is designed for this
treatment that is designed for this
treatment that is designed for this particular cancer so we now know that
particular cancer so we now know that
particular cancer so we now know that each of these cancer cells actually
each of these cancer cells actually
each of these cancer cells actually control by a specific gene and this gene
control by a specific gene and this gene
control by a specific gene and this gene is none other than your own gene they
is none other than your own gene they
is none other than your own gene they actually mutated so the word mutation
actually mutated so the word mutation
actually mutated so the word mutation air refer to an alteration of the gene
air refer to an alteration of the gene
air refer to an alteration of the gene sequences that caused by radiation
sequences that caused by radiation
sequences that caused by radiation environment and also surrounding and
environment and also surrounding and
environment and also surrounding and also chemicals so you look at the chart
also chemicals so you look at the chart
also chemicals so you look at the chart here so mutation on the particular
here so mutation on the particular
here so mutation on the particular sequences can cascade it down and a fang
sequences can cascade it down and a fang
sequences can cascade it down and a fang the translation of a minuses and also
the translation of a minuses and also
the translation of a minuses and also the end product so if you look at the
the end product so if you look at the
the end product so if you look at the word here are uses as an analogy I have
word here are uses as an analogy I have
word here are uses as an analogy I have a cat this is not proofreading if you
a cat this is not proofreading if you
a cat this is not proofreading if you look at it if
look at it if
look at it if you just changed a letter so it means
you just changed a letter so it means
you just changed a letter so it means the meaning change similarly to our own
the meaning change similarly to our own
the meaning change similarly to our own gene even a single letter change in a
gene even a single letter change in a
gene even a single letter change in a specific area of that particular gene is
specific area of that particular gene is
specific area of that particular gene is actually drive the cells to behave
actually drive the cells to behave
actually drive the cells to behave differently so now our body not only
differently so now our body not only
differently so now our body not only covers by only one segment of gene
covers by only one segment of gene
covers by only one segment of gene million of it so can you imagine so many
million of it so can you imagine so many
million of it so can you imagine so many records or data shown that if we detain
records or data shown that if we detain
records or data shown that if we detain this mutation earlier before the disease
this mutation earlier before the disease
this mutation earlier before the disease progression
progression
progression there are about 70% survival as compared
there are about 70% survival as compared
there are about 70% survival as compared to less fish and many of us know that if
to less fish and many of us know that if
to less fish and many of us know that if you detect the cancer late then it was
you detect the cancer late then it was
you detect the cancer late then it was spread so it is not about what type of
spread so it is not about what type of
spread so it is not about what type of treatment it does but it depends on how
treatment it does but it depends on how
treatment it does but it depends on how sensitive an approach to actually detect
sensitive an approach to actually detect
sensitive an approach to actually detect this cancer we all understand that maybe
this cancer we all understand that maybe
this cancer we all understand that maybe is the jargon so we understand that
is the jargon so we understand that
is the jargon so we understand that there are many modalities available to
there are many modalities available to
there are many modalities available to actually look into these cancers namely
actually look into these cancers namely
actually look into these cancers namely mammography gastro endoscopy low-dose CT
mammography gastro endoscopy low-dose CT
mammography gastro endoscopy low-dose CT all these techniques in only looking at
all these techniques in only looking at
all these techniques in only looking at the surfaces of the cancers but what
the surfaces of the cancers but what
the surfaces of the cancers but what that this modalities means is all those
that this modalities means is all those
that this modalities means is all those unknown cases the caused by the gene
unknown cases the caused by the gene
unknown cases the caused by the gene beneath these cancer cells so now in the
beneath these cancer cells so now in the
beneath these cancer cells so now in the field of molecular diagnostics what we
field of molecular diagnostics what we
field of molecular diagnostics what we need on what do we look is the
need on what do we look is the
need on what do we look is the particular changes I mentioned the
particular changes I mentioned the
particular changes I mentioned the mutation but this is not only the area
mutation but this is not only the area
mutation but this is not only the area that we cover but we know we also look
that we cover but we know we also look
that we cover but we know we also look into the details of how sensitive an
into the details of how sensitive an
into the details of how sensitive an approach that can detain as low as a
approach that can detain as low as a
approach that can detain as low as a single gene that is mutated in the cells
single gene that is mutated in the cells
single gene that is mutated in the cells so thanks to the interventions of
so thanks to the interventions of
so thanks to the interventions of biomedical scientists and all these
biomedical scientists and all these
biomedical scientists and all these engineers there are a lot of
engineers there are a lot of
engineers there are a lot of sophisticated tools such as next-gen
sophisticated tools such as next-gen
sophisticated tools such as next-gen sequencing digital PCR
sequencing digital PCR
sequencing digital PCR name it so many they actually help us to
name it so many they actually help us to
name it so many they actually help us to detain these particular cells at the
detain these particular cells at the
detain these particular cells at the genetic level so now just to replace
genetic level so now just to replace
genetic level so now just to replace that the precision medicines is not a
that the precision medicines is not a
that the precision medicines is not a traditional approach it is multi
traditional approach it is multi
traditional approach it is multi modalities or multi multi concepts which
modalities or multi multi concepts which
modalities or multi multi concepts which integrated the genes the treatment
integrated the genes the treatment
integrated the genes the treatment target treatment and also the cells and
target treatment and also the cells and
target treatment and also the cells and what most interesting now in the very
what most interesting now in the very
what most interesting now in the very near future you will see they will
near future you will see they will
near future you will see they will incorporate the immune which is your
incorporate the immune which is your
incorporate the immune which is your combat system in your body so when you
combat system in your body so when you
combat system in your body so when you look at molecular approaches especially
look at molecular approaches especially
look at molecular approaches especially the Diagnostics this now we realize that
the Diagnostics this now we realize that
the Diagnostics this now we realize that through these molecular approaches we
through these molecular approaches we
through these molecular approaches we can define and identify these mutated
can define and identify these mutated
can define and identify these mutated genes where is located because of the
genes where is located because of the
genes where is located because of the amount of these techniques previously
amount of these techniques previously
amount of these techniques previously reclassifying or the clinician
reclassifying or the clinician
reclassifying or the clinician classified cancer based on a particular
classified cancer based on a particular
classified cancer based on a particular site which is breast cancer liver cancer
site which is breast cancer liver cancer
site which is breast cancer liver cancer kidney cancer but with the amounts ‘men
kidney cancer but with the amounts ‘men
kidney cancer but with the amounts ‘men of the molecular diagnostics now the
of the molecular diagnostics now the
of the molecular diagnostics now the approach allowed the clinicians to
approach allowed the clinicians to
approach allowed the clinicians to redefine and reclassify
redefine and reclassify
redefine and reclassify these particular answer based on the
these particular answer based on the
these particular answer based on the particular mutation such as listed on my
particular mutation such as listed on my
particular mutation such as listed on my left so with this particular mutation
left so with this particular mutation
left so with this particular mutation now and thanks to the scientists that
now and thanks to the scientists that
now and thanks to the scientists that have developed a certain compounds or
have developed a certain compounds or
have developed a certain compounds or certain drugs to address this particular
certain drugs to address this particular
certain drugs to address this particular mutation so let’s look at the particular
mutation so let’s look at the particular
mutation so let’s look at the particular normal cell how is actually derived to
normal cell how is actually derived to
normal cell how is actually derived to become cancerous and subsequent how that
become cancerous and subsequent how that
become cancerous and subsequent how that these particular treatment confer a
these particular treatment confer a
these particular treatment confer a resistance e on these particular cancer
resistance e on these particular cancer
resistance e on these particular cancer cells so we realize that in normal cells
cells so we realize that in normal cells
cells so we realize that in normal cells undergoing the casino genesis due to
undergoing the casino genesis due to
undergoing the casino genesis due to mutation the tumors will form okay so
mutation the tumors will form okay so
mutation the tumors will form okay so now just now i highlighted that there
now just now i highlighted that there
now just now i highlighted that there are some treatments to
are some treatments to
are some treatments to the mutation correct so the mutation
the mutation correct so the mutation
the mutation correct so the mutation will address and we’ll treat these
will address and we’ll treat these
will address and we’ll treat these tumors however in this lump of tumors
tumors however in this lump of tumors
tumors however in this lump of tumors there are some portion of the cells will
there are some portion of the cells will
there are some portion of the cells will milk it again to confirm resistance
milk it again to confirm resistance
milk it again to confirm resistance these are all cells they need to survive
these are all cells they need to survive
these are all cells they need to survive is the evolution so some of these cells
is the evolution so some of these cells
is the evolution so some of these cells remain will undergo system resistant
remain will undergo system resistant
remain will undergo system resistant mutation and what next that these
mutation and what next that these
mutation and what next that these mutated cells will flare off become
mutated cells will flare off become
mutated cells will flare off become another resistant tumors but what the
another resistant tumors but what the
another resistant tumors but what the drugs available now you will see that
drugs available now you will see that
drugs available now you will see that there are many generations of drugs
there are many generations of drugs
there are many generations of drugs targeted therapy not to address the
targeted therapy not to address the
targeted therapy not to address the initiatives but also the resistance
initiatives but also the resistance
initiatives but also the resistance tumors thanks to the molecular
tumors thanks to the molecular
tumors thanks to the molecular diagnostic approaches you can then
diagnostic approaches you can then
diagnostic approaches you can then differentiate the initiative er to the
differentiate the initiative er to the
differentiate the initiative er to the one resistant so this is not something
one resistant so this is not something
one resistant so this is not something that is in the story but it is something
that is in the story but it is something
that is in the story but it is something that’s available so you can see that
that’s available so you can see that
that’s available so you can see that there are many drugs available to
there are many drugs available to
there are many drugs available to address this type of alteration and you
address this type of alteration and you
address this type of alteration and you will see that the next line there are
will see that the next line there are
will see that the next line there are many ongoing improved generations of
many ongoing improved generations of
many ongoing improved generations of drugs to address this resistance
drugs to address this resistance
drugs to address this resistance mutation or resistance cells so if you
mutation or resistance cells so if you
mutation or resistance cells so if you look at the current modalities where you
look at the current modalities where you
look at the current modalities where you just look at the cells alone you will be
just look at the cells alone you will be
just look at the cells alone you will be able to see that the cells mutation of
able to see that the cells mutation of
able to see that the cells mutation of the gene however with more likely
the gene however with more likely
the gene however with more likely dynasty you need to take out the cells
dynasty you need to take out the cells
dynasty you need to take out the cells and then digest and get the DNA and
and then digest and get the DNA and
and then digest and get the DNA and subsequently detect the mutation and of
subsequently detect the mutation and of
subsequently detect the mutation and of course with that you’ll be able to treat
course with that you’ll be able to treat
course with that you’ll be able to treat the particular cancer so because of the
the particular cancer so because of the
the particular cancer so because of the advancement of the molecular diagnostics
advancement of the molecular diagnostics
advancement of the molecular diagnostics now it is not that it is has been
now it is not that it is has been
now it is not that it is has been incorporated into the normal schematic
incorporated into the normal schematic
incorporated into the normal schematic journeys of a patient you will see that
journeys of a patient you will see that
journeys of a patient you will see that here the molecular diagnosis now looking
here the molecular diagnosis now looking
here the molecular diagnosis now looking at
at
at the gene segment will assist the
the gene segment will assist the
the gene segment will assist the clinicians to make that decision upon a
clinicians to make that decision upon a
clinicians to make that decision upon a particular treatment and also is used as
particular treatment and also is used as
particular treatment and also is used as for disease progressions monitoring so
for disease progressions monitoring so
for disease progressions monitoring so again thanks to the development of the
again thanks to the development of the
again thanks to the development of the equipment and the sensitivity this is
equipment and the sensitivity this is
equipment and the sensitivity this is now I mentioned about one particular
now I mentioned about one particular
now I mentioned about one particular site detection so now there is a lot of
site detection so now there is a lot of
site detection so now there is a lot of modalities thanks to like next gene
modalities thanks to like next gene
modalities thanks to like next gene sequencing you’ll be able to see that at
sequencing you’ll be able to see that at
sequencing you’ll be able to see that at one time you’ll be able to see different
one time you’ll be able to see different
one time you’ll be able to see different mutation at different cells at one time
mutation at different cells at one time
mutation at different cells at one time so what benefits here
so what benefits here
so what benefits here the patient will pay less and most
the patient will pay less and most
the patient will pay less and most importantly now the patient we can see
importantly now the patient we can see
importantly now the patient we can see what the butler’s cells have mutated and
what the butler’s cells have mutated and
what the butler’s cells have mutated and where does this mutation on the gene
where does this mutation on the gene
where does this mutation on the gene goes into different site of the
goes into different site of the
goes into different site of the particular organs so I have prepared a
particular organs so I have prepared a
particular organs so I have prepared a particular video to show you that it is
particular video to show you that it is
particular video to show you that it is not this but composition medicine is not
not this but composition medicine is not
not this but composition medicine is not something high but it is true not only
something high but it is true not only
something high but it is true not only happens in the US or the Western we have
happens in the US or the Western we have
happens in the US or the Western we have a very own patients who actually benefit
a very own patients who actually benefit
a very own patients who actually benefit from this treatment my name is Linda
from this treatment my name is Linda
from this treatment my name is Linda balls I’m 87 years old I like to listen
balls I’m 87 years old I like to listen
balls I’m 87 years old I like to listen a lot of music I also love gardening and
a lot of music I also love gardening and
a lot of music I also love gardening and I’m very active member of the church
I’m very active member of the church
I’m very active member of the church basically I’m having a very interesting
basically I’m having a very interesting
basically I’m having a very interesting life end of 2015 I was sent to call to
life end of 2015 I was sent to call to
life end of 2015 I was sent to call to have a CT scan and when the result came
have a CT scan and when the result came
have a CT scan and when the result came out they thought I was suffering from
out they thought I was suffering from
out they thought I was suffering from tabula casas because of my black spots
tabula casas because of my black spots
tabula casas because of my black spots in my lungs so again they will mean to
in my lungs so again they will mean to
in my lungs so again they will mean to have a second x-ray asthma and I waited
have a second x-ray asthma and I waited
have a second x-ray asthma and I waited for a week and then it was confirmed
for a week and then it was confirmed
for a week and then it was confirmed that I have quite cancer everybody was
that I have quite cancer everybody was
that I have quite cancer everybody was shocked they would believe that I have
shocked they would believe that I have
shocked they would believe that I have this
this
this messing me a first diagnosis professor
messing me a first diagnosis professor
messing me a first diagnosis professor lund put me on this duck call Eric’s our
lund put me on this duck call Eric’s our
lund put me on this duck call Eric’s our and I was very very happy with it
and I was very very happy with it
and I was very very happy with it because the cancer marker was 200
because the cancer marker was 200
because the cancer marker was 200 something is down to 76 or something I
something is down to 76 or something I
something is down to 76 or something I can’t remember the figure and then later
can’t remember the figure and then later
can’t remember the figure and then later on and when I went for CT scan again it
on and when I went for CT scan again it
on and when I went for CT scan again it went up again so professor says well
went up again so professor says well
went up again so professor says well this drug is not suitable for you
this drug is not suitable for you
this drug is not suitable for you anymore
anymore
anymore so he took my blood test it was very
so he took my blood test it was very
so he took my blood test it was very kind of him you put him a lot of trouble
kind of him you put him a lot of trouble
kind of him you put him a lot of trouble for my case and he sent my blood to Hong
for my case and he sent my blood to Hong
for my case and he sent my blood to Hong Kong I took this new drug since April
Kong I took this new drug since April
Kong I took this new drug since April and I was so happy to hear that from my
and I was so happy to hear that from my
and I was so happy to hear that from my blood tests for the cancer marker and I
blood tests for the cancer marker and I
blood tests for the cancer marker and I took only 2 months of it and it came
took only 2 months of it and it came
took only 2 months of it and it came down to seventeen point nine which is
down to seventeen point nine which is
down to seventeen point nine which is very very good it my stew seems to be
very very good it my stew seems to be
very very good it my stew seems to be normal again
normal again
normal again and also that term the crumbs in my nose
and also that term the crumbs in my nose
and also that term the crumbs in my nose that has stopped also and the pimples in
that has stopped also and the pimples in
that has stopped also and the pimples in my head has also gone and I’m very very
my head has also gone and I’m very very
my head has also gone and I’m very very happy I read that this drug is really
happy I read that this drug is really
happy I read that this drug is really doing good for me and I’m very happy
doing good for me and I’m very happy
doing good for me and I’m very happy that everybody who looks at me say I
that everybody who looks at me say I
that everybody who looks at me say I don’t look like a cancer patient the
don’t look like a cancer patient the
don’t look like a cancer patient the doctor should give explain to them but
doctor should give explain to them but
doctor should give explain to them but the drugs do for them this is a very
the drugs do for them this is a very
the drugs do for them this is a very good example for them and just by
good example for them and just by
good example for them and just by explaining to them the drug is doing so
explaining to them the drug is doing so
explaining to them the drug is doing so good to this patient why don’t you have
good to this patient why don’t you have
good to this patient why don’t you have a try on this new drug and see don’t
a try on this new drug and see don’t
a try on this new drug and see don’t think so much and so get so depressed
think so much and so get so depressed
think so much and so get so depressed about the sickness the positive thinking
about the sickness the positive thinking
about the sickness the positive thinking is very important
so precision mesons is not a particular
so precision mesons is not a particular talking about drug it is a
talking about drug it is a
talking about drug it is a multi-dimensional concept it is about
multi-dimensional concept it is about
multi-dimensional concept it is about the drug the diagnosis and also the
the drug the diagnosis and also the
the drug the diagnosis and also the intervention so thanks to the
intervention so thanks to the
intervention so thanks to the development of all these molecular
development of all these molecular
development of all these molecular diagnostics now patients enjoy a
diagnostics now patients enjoy a
diagnostics now patients enjoy a pain-free approaches using just the
pain-free approaches using just the
pain-free approaches using just the blood you’ll be able to see a certain
blood you’ll be able to see a certain
blood you’ll be able to see a certain molecular diagnostic of the changes of
molecular diagnostic of the changes of
molecular diagnostic of the changes of these cancer cells the area that I
these cancer cells the area that I
these cancer cells the area that I research is focusing on identifying
research is focusing on identifying
research is focusing on identifying these biomarkers and also some small
these biomarkers and also some small
these biomarkers and also some small switches that control the mutations and
switches that control the mutations and
switches that control the mutations and also the progressions of cancer as
also the progressions of cancer as
also the progressions of cancer as molecular biologists I also serve to the
molecular biologists I also serve to the
molecular biologists I also serve to the hospital to identify a certain
hospital to identify a certain
hospital to identify a certain techniques which are sensitive approved
techniques which are sensitive approved
techniques which are sensitive approved and good enough to identify and screen
and good enough to identify and screen
and good enough to identify and screen on this cancer so spread your words that
on this cancer so spread your words that
on this cancer so spread your words that precision medicines is not that high is
precision medicines is not that high is
precision medicines is not that high is a reality and with that prevention is
a reality and with that prevention is
a reality and with that prevention is better than cure but some of us may
better than cure but some of us may
better than cure but some of us may over-interpreting this mutation so in
over-interpreting this mutation so in
over-interpreting this mutation so in line with the theme of TEDx Khanna that
line with the theme of TEDx Khanna that
line with the theme of TEDx Khanna that body mind and soul that body is one that
body mind and soul that body is one that
body mind and soul that body is one that the molecular diagnostics can detain the
the molecular diagnostics can detain the
the molecular diagnostics can detain the mind is what decision that you made and
mind is what decision that you made and
mind is what decision that you made and wrong decision that actually leads to
wrong decision that actually leads to
wrong decision that actually leads to your souls which is the rest in peace
your souls which is the rest in peace
your souls which is the rest in peace thank you
thank you
thank you [Applause]
[Applause]
[Applause] [Music]
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