[Music]
I would like to share with you a story
a person that we will call na
Anna is a woman considers herself
same healthy
is 32 years old, does not smoke
do not drink alcohol never used drugs
However, since she was 18 years old,
age
started for no apparent reason to
experience feelings of emptiness a
deep sadness that I did not identify in
the cause
he lost the ability to enjoy things
that she normally enjoyed doing
how to live with your family
have your partner listen to music go out to
take a walk
were these changes so remarkable in their
behavior and in their way of life that their
own family was asked worried
for her and started looking for some
explanation to understand what it was that
it was happening
They went with a doctor and the doctor
gave the diagnosis of disorder
major depressive
she is already 14 years old with this
diagnosis has gone through a number
of treatments
and has not achieved adequate control of
these symptoms have had four attempts
of taking your own life in the face of frustration
of not being able to control that sadness of not
be able to control those feelings
negative that sometimes I do it well and it was
just after this last
I try to go with me
when he comes, we make a protocol
to identify some other cause that
could be generating these these
symptoms and rule out diseases
We make adjustments in the
treatments that I had already added
other medications
and we did not get the results that
We were waiting
she felt so frustrated as me and
I began to express that I was going back to
consider the idea of taking your own life
before this despair and before this
anxiety that generated thinking that
I was always going to live suffering with this
suffering
it was then when I last as
alternative that you had at hand
I proposed starting a therapy
experimental
with a medication that has not yet
finds approved for treatment
of these symptoms but has presented
promising results in both states
united as worldwide
to give them a bit of context
I’m going to give some figures about the
depression
in the world there are currently more than
300 million people suffering
depression
this has returned to depression the
main cause of disability in the
world and with suicide as his
main complication is the second
cause of death for people between
15 and 29 years
in mexico according to inegi data
They kill more than 6000 people a year and
These numbers have been increasing to the point
that the predictions tell us that
for the year 2020 it will be the main
cause of death worldwide
suicide associated with disorders of the
mood
these data are alarming and if to this
we award him we add the fact of
what
even people who do respond to
an antidepressant treatment one third
of them will present a relapse or
two relapses throughout his life
and that a third of the people who
receive a treatment for depression
will not respond until after
use three or more medications come back
the predictions for depression like
more somber
how can we understand depression the
depression is a mental illness
it’s a disease they have a foundation
physical in the way that the
brain
and it is given by a set of factors
they come from individual factors that
would be changes in the structure the
brain chemistry given by consumption of
Substances due to trauma history
for tumor infections factors
genetic a person who has parents
who have suffered depression has three
times more risk of suffering
disease compared to other
person who has healthy parents in
identical twins and a twin
has depression the other has a 70
a hundred times more likely
suffer from this disease in comparison
with another pair of healthy twins
it’s from other factors also it
find factors of the
personality of a person a person
that has low self-esteem that does not
responds well to frustration
he also has a greater risk of suffering
the disease the environment in the
that we go back to live in environments
toxic from being exposed to violence
physical psychological violence
Being under a lot of stress problems
social work relatives
all these factors converge and in
susceptible people cause it to detonate or
that the symptoms of the
symptoms of the disease
what happens since we have the
good disease our brain starts
to present a series of changes
chemicals in which some
substances decrease their activity
others increase these substances are
known as neurotransmitters are
responsible for communication between
different structures of the brain and the
own brain with the rest of the
organism and this dysfunction is what
generates the symptoms that we all know
with we hear the word depression the
sadness the ideas that we are not worth the
lack of energy lack of motivation
etc
a depressed person tell them to present
all these negative feelings
it’s not a matter of attitude it’s not a
question of not wanting
physically incapacitated to be able
see things in the way that a
we would like them to
they saw their moment
and that’s what I want to explain to you a little
I want to talk about the foundation
scientist that explains why the
person can not leave anything else with
attitude that there is a region that
just recently identified in the
brain
that suppresses what we would call
as the center of pleasure there is a
part of our brain a circuit a
series of regions that connect between
yes it is called the system of
reward this system evolutionarily
speaks to us has helped us
form habits or have certain
behaviors and our brain rewards us
in a certain way we provide a sensation
of wellbeing to exercise the
eat the rich sleep all that gives us
certain pleasure and it is this region that we
is encouraging us to do it
our serious says it’s okay and that
we should continue doing it
there is a region that has to
compensate for this function then it has
identified this region as the bird
lateral null
we can call the anti system
reward that what it does is suppress
that system so that for behaviors
contrary
then recent studies have
identified that in the depression this
anti reward system is counted
about activated or hyper activated that is
what it does completely blocks us
this ability to enjoy for
feel pleasure to find us
motivated to have energy
the symptoms that we have been discussing
similarly recent studies we
they have stung
that there are substances that act
specifically in this anti system
reward blocking your signal avoiding
that stops the reward system
these substances that have been identified
recently they share a
characteristic are psychoactive drugs
what does this mean are drugs that
produce hallucinations that produce
this psychedelic effect like
psilocybin that is the substance that is
find the hallucinogenic mushrooms llc
drugs like ketamine which is the one
I’m editing and taking as main
element for this talk
which is also an anesthetic is
used both in veterinary medicine and in
medicine in general
this anesthetic has the property of
that blocks 30 minutes of having
administered blocks completely in the
activity of this region
and this block is maintained up to two
weeks after having administered it
which gives us a remission of the
symptoms of a depressed person
surprising way we are talking about
that the half hour that I apply
the medication she is already going to have a
completely different attitude
and that was precisely what I gave him
I proposed anna after having exhausted
the possibilities that we had at hand
I told him about the potential risks
what could I have and the benefits that I
I expected him to get this
treatment with this information she
agreed to carry out the clinical trial and
The first thing we did was add a
scale I asked a series of questions a
questionnaire in which I evaluated the
symptoms of depression to be able to see
how severe they were in her before
start the treatment the score that
I felt sorry for a compatible
very severe depression
we administer the treatment and
next days apply again the
scale
the results that she presented in the
second take of the sample were
compatible with mild depression
Anda has already been four months
we started the therapy is being treated
with a minimal dose of antidepressants and
the symptoms of depression have not
turned
and he is motivated and happy his words
a long time she has a new
perspective on life and especially
he no longer sees depression as a sentence
of death for her
the use of these substances raises
ethical and moral dilemmas I’m not
saying that it is the solution for all
the cases there are situations in which
you can manage to manage people who
has a potential for abuse in order to
accounts has psychoactive effects and
can be abused as a drug because it is not
you can manage people who have
background of psychotic pictures by
the same psychedelic effects that
can come to present can not be
manage
but this is another part of the
people who do not have these two
criteria we could tell you that it
they can see potentially benefited
with this type of treatment
in this particular case of which
also in the doses that are used are
much lower than those used in
general anesthesia any risk or
side effect that the
Substance abuse is neutralized
practically for the doses so low and
the benefit far outweighs the
small risk that could reach
carry
in the USA it is not proven yet
by faith , however, as I repeat
for being a medicine if you can
carry out clinical trials and projects
research and thanks to that many
universities and clinics have been
taking many studies around the
world checking this therapy
checking this efficiency and trying to
identify the particle or the substance
specific free component
addictive psychoactive that can
cause those symptoms so that
develop better drugs and more
specific that can be used with
much more freedom with much more
tranquility
we know that at the global level, now
dilemma of the legalization of drugs
is on everyone’s lips
and I’m not talking about legalizing or
about talking about stop demonizing the
use of the substances to which I
I mean, even marijuana
who had told them about drugs
psychoactive has been proven to have
a beneficial effect for very diseases
individuals difficult to control and who
many times it is the best alternative or
the only alternative that can be reached
to use should be created better
public policies should be
legislate in favor of experimentation and
the investigation with these substances
to be able to identify the particles
free from the addictive effect it gives us in
this effect that we are
finding so surprisingly
beneficial in people
this talk brings in my mind the call
Paracelsus principle
for celso he was a doctor and alchemist
which was very famous little known as the
father of toxicology because of his
Experiments with poisonous substances
things that people considered toxic
he worked under a premise that
paraphrased more or less said the dose
towards the poison
what does this mean
substance
even the water can become
harmful to us I will become
lethal for us in the doses
appropriate and in the same way there are
poisons we’ve seen about poisons from
black widow’s poison scorpion
metals like lithium there are drugs
like ketamine the hallucinogenic mushrooms
llc
who have proven that in the doses
adequate
They are effective in dealing with problems that
it seems that there is no other solution that does not
there is another alternative so important or
as effective as them
so my intention with this talk
tell them the case of anna is that
let’s have a more complete picture about
of how these diseases have a
So devastating effect and growth
almost epidemic we all know someone
who has depression or who has had
depression or who will have depression
imagine us doctors
when we are going to start our practice
professional
we take the so-called oath of
Hippocrates
in the oath of hippocrates we
we say roughly that we’re going to
do everything in our power
for the well-being of people who
they are distressed
if I am finding substances if I
I’m finding medicines
alternatives that may come to try
one of the most devastating diseases
of the 21st century my question and my reflection
What I want to leave you with is why not
we should try
thank you very much
[Applause]
I would like to share with you a story
a person that we will call na
Anna is a woman considers herself
same healthy
is 32 years old, does not smoke
do not drink alcohol never used drugs
However, since she was 18 years old,
age
started for no apparent reason to
experience feelings of emptiness a
deep sadness that I did not identify in
the cause
he lost the ability to enjoy things
that she normally enjoyed doing
how to live with your family
have your partner listen to music go out to
take a walk
were these changes so remarkable in their
behavior and in their way of life that their
own family was asked worried
for her and started looking for some
explanation to understand what it was that
it was happening
They went with a doctor and the doctor
gave the diagnosis of disorder
major depressive
she is already 14 years old with this
diagnosis has gone through a number
of treatments
and has not achieved adequate control of
these symptoms have had four attempts
of taking your own life in the face of frustration
of not being able to control that sadness of not
be able to control those feelings
negative that sometimes I do it well and it was
just after this last
I try to go with me
when he comes, we make a protocol
to identify some other cause that
could be generating these these
symptoms and rule out diseases
We make adjustments in the
treatments that I had already added
other medications
and we did not get the results that
We were waiting
she felt so frustrated as me and
I began to express that I was going back to
consider the idea of taking your own life
before this despair and before this
anxiety that generated thinking that
I was always going to live suffering with this
suffering
it was then when I last as
alternative that you had at hand
I proposed starting a therapy
experimental
with a medication that has not yet
finds approved for treatment
of these symptoms but has presented
promising results in both states
united as worldwide
to give them a bit of context
I’m going to give some figures about the
depression
in the world there are currently more than
300 million people suffering
depression
this has returned to depression the
main cause of disability in the
world and with suicide as his
main complication is the second
cause of death for people between
15 and 29 years
in mexico according to inegi data
They kill more than 6000 people a year and
These numbers have been increasing to the point
that the predictions tell us that
for the year 2020 it will be the main
cause of death worldwide
suicide associated with disorders of the
mood
these data are alarming and if to this
we award him we add the fact of
what
even people who do respond to
an antidepressant treatment one third
of them will present a relapse or
two relapses throughout his life
and that a third of the people who
receive a treatment for depression
will not respond until after
use three or more medications come back
the predictions for depression like
more somber
how can we understand depression the
depression is a mental illness
it’s a disease they have a foundation
physical in the way that the
brain
and it is given by a set of factors
they come from individual factors that
would be changes in the structure the
brain chemistry given by consumption of
Substances due to trauma history
for tumor infections factors
genetic a person who has parents
who have suffered depression has three
times more risk of suffering
disease compared to other
person who has healthy parents in
identical twins and a twin
has depression the other has a 70
a hundred times more likely
suffer from this disease in comparison
with another pair of healthy twins
it’s from other factors also it
find factors of the
personality of a person a person
that has low self-esteem that does not
responds well to frustration
he also has a greater risk of suffering
the disease the environment in the
that we go back to live in environments
toxic from being exposed to violence
physical psychological violence
Being under a lot of stress problems
social work relatives
all these factors converge and in
susceptible people cause it to detonate or
that the symptoms of the
symptoms of the disease
what happens since we have the
good disease our brain starts
to present a series of changes
chemicals in which some
substances decrease their activity
others increase these substances are
known as neurotransmitters are
responsible for communication between
different structures of the brain and the
own brain with the rest of the
organism and this dysfunction is what
generates the symptoms that we all know
with we hear the word depression the
sadness the ideas that we are not worth the
lack of energy lack of motivation
etc
a depressed person tell them to present
all these negative feelings
it’s not a matter of attitude it’s not a
question of not wanting
physically incapacitated to be able
see things in the way that a
we would like them to
they saw their moment
and that’s what I want to explain to you a little
I want to talk about the foundation
scientist that explains why the
person can not leave anything else with
attitude that there is a region that
just recently identified in the
brain
that suppresses what we would call
as the center of pleasure there is a
part of our brain a circuit a
series of regions that connect between
yes it is called the system of
reward this system evolutionarily
speaks to us has helped us
form habits or have certain
behaviors and our brain rewards us
in a certain way we provide a sensation
of wellbeing to exercise the
eat the rich sleep all that gives us
certain pleasure and it is this region that we
is encouraging us to do it
our serious says it’s okay and that
we should continue doing it
there is a region that has to
compensate for this function then it has
identified this region as the bird
lateral null
we can call the anti system
reward that what it does is suppress
that system so that for behaviors
contrary
then recent studies have
identified that in the depression this
anti reward system is counted
about activated or hyper activated that is
what it does completely blocks us
this ability to enjoy for
feel pleasure to find us
motivated to have energy
the symptoms that we have been discussing
similarly recent studies we
they have stung
that there are substances that act
specifically in this anti system
reward blocking your signal avoiding
that stops the reward system
these substances that have been identified
recently they share a
characteristic are psychoactive drugs
what does this mean are drugs that
produce hallucinations that produce
this psychedelic effect like
psilocybin that is the substance that is
find the hallucinogenic mushrooms llc
drugs like ketamine which is the one
I’m editing and taking as main
element for this talk
which is also an anesthetic is
used both in veterinary medicine and in
medicine in general
this anesthetic has the property of
that blocks 30 minutes of having
administered blocks completely in the
activity of this region
and this block is maintained up to two
weeks after having administered it
which gives us a remission of the
symptoms of a depressed person
surprising way we are talking about
that the half hour that I apply
the medication she is already going to have a
completely different attitude
and that was precisely what I gave him
I proposed anna after having exhausted
the possibilities that we had at hand
I told him about the potential risks
what could I have and the benefits that I
I expected him to get this
treatment with this information she
agreed to carry out the clinical trial and
The first thing we did was add a
scale I asked a series of questions a
questionnaire in which I evaluated the
symptoms of depression to be able to see
how severe they were in her before
start the treatment the score that
I felt sorry for a compatible
very severe depression
we administer the treatment and
next days apply again the
scale
the results that she presented in the
second take of the sample were
compatible with mild depression
Anda has already been four months
we started the therapy is being treated
with a minimal dose of antidepressants and
the symptoms of depression have not
turned
and he is motivated and happy his words
a long time she has a new
perspective on life and especially
he no longer sees depression as a sentence
of death for her
the use of these substances raises
ethical and moral dilemmas I’m not
saying that it is the solution for all
the cases there are situations in which
you can manage to manage people who
has a potential for abuse in order to
accounts has psychoactive effects and
can be abused as a drug because it is not
you can manage people who have
background of psychotic pictures by
the same psychedelic effects that
can come to present can not be
manage
but this is another part of the
people who do not have these two
criteria we could tell you that it
they can see potentially benefited
with this type of treatment
in this particular case of which
also in the doses that are used are
much lower than those used in
general anesthesia any risk or
side effect that the
Substance abuse is neutralized
practically for the doses so low and
the benefit far outweighs the
small risk that could reach
carry
in the USA it is not proven yet
by faith , however, as I repeat
for being a medicine if you can
carry out clinical trials and projects
research and thanks to that many
universities and clinics have been
taking many studies around the
world checking this therapy
checking this efficiency and trying to
identify the particle or the substance
specific free component
addictive psychoactive that can
cause those symptoms so that
develop better drugs and more
specific that can be used with
much more freedom with much more
tranquility
we know that at the global level, now
dilemma of the legalization of drugs
is on everyone’s lips
and I’m not talking about legalizing or
about talking about stop demonizing the
use of the substances to which I
I mean, even marijuana
who had told them about drugs
psychoactive has been proven to have
a beneficial effect for very diseases
individuals difficult to control and who
many times it is the best alternative or
the only alternative that can be reached
to use should be created better
public policies should be
legislate in favor of experimentation and
the investigation with these substances
to be able to identify the particles
free from the addictive effect it gives us in
this effect that we are
finding so surprisingly
beneficial in people
this talk brings in my mind the call
Paracelsus principle
for celso he was a doctor and alchemist
which was very famous little known as the
father of toxicology because of his
Experiments with poisonous substances
things that people considered toxic
he worked under a premise that
paraphrased more or less said the dose
towards the poison
what does this mean
substance
even the water can become
harmful to us I will become
lethal for us in the doses
appropriate and in the same way there are
poisons we’ve seen about poisons from
black widow’s poison scorpion
metals like lithium there are drugs
like ketamine the hallucinogenic mushrooms
llc
who have proven that in the doses
adequate
They are effective in dealing with problems that
it seems that there is no other solution that does not
there is another alternative so important or
as effective as them
so my intention with this talk
tell them the case of anna is that
let’s have a more complete picture about
of how these diseases have a
So devastating effect and growth
almost epidemic we all know someone
who has depression or who has had
depression or who will have depression
imagine us doctors
when we are going to start our practice
professional
we take the so-called oath of
Hippocrates
in the oath of hippocrates we
we say roughly that we’re going to
do everything in our power
for the well-being of people who
they are distressed
if I am finding substances if I
I’m finding medicines
alternatives that may come to try
one of the most devastating diseases
of the 21st century my question and my reflection
What I want to leave you with is why not
we should try
thank you very much
[Applause]
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