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Transplantes | José Medina Pestana | TEDxUNIFESP


then comes the word transplant
no one imagines so the complexity
which has around a transplant
transplantation with deceased donor one
person died at an early stage had
brain death and turned the donor
family drama that sentiment data
premature death and unexpected loss
You have to decide whether to donor
agencies will not authorize or not
donation and have the rental agency
have to have a regulation would
then you allocate the angle in the first
Queue patient for it because until
You can thus have the
credibility of the company
On the other hand transplantation with donor
live you have someone who will donate
a body that goes on underwent a
surgery will stick to the body – without
mainly based on need
affective relationship he has with
another person
it is curious that so happens when
father or mother
this more intense affective relationship
There is no parent talks going
will not give to the child and the other
side when a child wants or needs
support father looks that we talked to
father occupied with talking mother
he is too young now the expectation
life is very very very long
he may need two risks
They live 85 years to life expectancy
who is 20 years old today 85 86 over
90 years the father said I think I will not
accepting performance the child cries the child
cries talk I want to donate any
way the child is not thinking 85
20 years now has has 30 years and it is
he’s thinking but the father speaks
so I’m on dialysis
I’m fine in daily I know the
transplant is better but this
difference it is not enough to
I justify leaving my only son
then transplantation as I said has
complexity in its environment is very
great need of social control
the Brazil has a social control to cin
lush has a national system of
transplant in Brasilia each state
Brazil has a coordination
state says
transplantation is that coordination
dictator this school coordination
state
Brazil is the largest program
World public transport
it is the second state was more
transparent than Brazil but within
the public system who does more
transplantation is the state is is Brazil
this is a 14th century framework
the show is an event that is a
is a legend of the century 3 2
Saints Saints Cosmas and Damian at the time
they were medical doctors were Arabs
who were educated in Greece that was
doing this transplant here in Rome in
Rome is a gladiator and pop deceased
in combat his leg was removed and
placed’m not old Christian that
time had no structure nothing
only was it the imposition of fabric and says
Legend has it that he walked out
and immediately to Main and ready
their provocation was to speak
equipment is old
this is only a legend but this adds
and if this situation it is distributed
in all the churches around the world
it helps immensely because
resistance of religions donation
or organ transplantation is minimal
mine to Jehovah’s witness who does not
accept the donation of blood is no
certainties in the blood has no
no any restriction on
live donor transplantation as both
deceased donor and also giving
organs in our contemporary world and
if the teacher joseph moore who did
first kidney transplant in 1954 in
boston and univitelino twin was the
first transplant success made in
1954 and he established technique
surgery that is used to this day I
I had the unique opportunity to meet
a few years ago two or three
years ago
he was 94 and was like
professor at harvard all I had
opportunity to meet for two days
They have contact with him for two days and
draws attention to 94 years or the
energy emanating from this phase
the unleavened out of this facility one
winner and is the conversation it is not
a conversation whining
in my time it was so far this time
no one wants anything to do with anything not spoken
that
he talked to me about our
time
why here we are here who
He is sitting with him just me
let me just listen and listen so the
that he spoke
before him his medal also en
He won the Nobel Prize for Medicine and was
who discovered he was born in Brazil
Brazil was born in his father was the
mechanical engineer who was
working in Rio de Janeiro he was born
in Brazil and returned to the
England after 44 years of age and
he found that transplanting who does
transplant rejection is the system
deficit and he opened up the possibility
you intervene in that system then
first intervention had
quite obvious intervention is obvious if
who destroys the transplant is the system
lymphoid we make a radiation
total lymphoid system and will avoid
the election gave straight – laced and Victor
rejection but no one in a person
these people recognized more
bacterial infection had not
rejection but she died of infection
then just went right to the transplant
Twin univitelino in 1960 here was
discovered as opines that also
blocks almost all the reinforcements but
more selectively blocking
taxes that are targeted by
while we are trying to do
rejection and after 1980 to here
transport should be done only between
univitelino twin has to be done
tito with the type of living donor and
also against the actor plans
Brazil late in the first was made
in 1965 by the teacher on Saturday in
the other organs heart lung
liver were still as well as the work
from 1980 to here as pioneers
it was discovered that the Kulina which is
highlighted is a more specific drug
Safer to influence the rejection
– in the response to infection and
It is more effective then
heart lung liver games that
not work at the time
the individual die that year 21
running time is a little
there he start work to be done and
now part of the routine of my
plans
all these organs are transplanted
routine just as bad is
transported today and if you look
and baby in this chart for 2000
here had no new drug that
appeared which was made part of the arsenal
therapeutic examination face 7 beta its name
but so complex that others
other names that is written therein
It seems they are all more or less
complex but it always more complex
even in the form of administration
his
I am not the minister and this remedy one
once a month
no need to take the medication adherence
of patients and it would be great
or I have a number of unknowns
yet we have used here in Brazil and
clean treatment and trial but
we do not have a definition that is
medicine will be even embedded
definitely on our in national
therapy
regardless of that 15 years without any
remedy the result of all
transplants has improved
gradually
as everything you do with repetition
the same process will systematically
repeating the team is improving here
this blog that yellow box
we are seeing in transplants
project in a transplant program
large scale that was made in 1908 2003
yellow box shows the curve
survival is called that here called curve
actuarial survival now a chance
a transplant succeeds after a
year with deceased donor living donor
result is better is smaller than 80%
this first curve the curve which is
down here the vessel which has the last
curve is the curve of the last four
years shows a result that is a chance
to succeed with the transplant donor
late is more than 90%
so no new discovery in the line
systematic repetition of the same
procedure
the result of improved transplant
rather these years so everyone
question which everyone asks now
and the line every time you listen ask
when will it end
is easy to answer that this first
column corneal transplant queue
is another thing can not be donated to
six hours after the heart has not stopped
have age limit does not have to take
remedy does not bounce then
practically there is not so much the daughter
korda from anywhere in the world says
Brazil in some states there is here in
State sao paulo in three months
you have amazed
we do meet a need of
corneal transplant 90
corneal transplants per million
inhabitants per year
kidney transplantation needed to do 50
60 we can do half of these
transplants and this queue is she going
increasing in Brazil has 120 thousand people
on chronic dialysis or more problem
least half of them could be
transplanted we can do
only half of these transport to a
liver transplant heart lung
little daughter
adding they all have least two thousand
people in line
this because the patient was not
transplanted in one year
today until amazed he then passed away
little daughter kidney transplant was
not for the bumps and be problem
as chronic dialysis
I have a patient is over 30 years
in daily that could not be
transplanted for various reasons
is bad but it is a way of people who
‘re 30 years on dialysis and works in
beautiful and works works works
normally
now what is the main issue
so we experienced in relation to
currently there transplant
so we observe that this map
most of this map it shows a
very large geographical disparity
both the transplant program where
you see the dark green is that it has
a very large traffic
more than 70 transplants per million
inhabitants per year
the white has no and Brazil
is here that color in this current
remedy this is this is a situation
absurd to experience this disparity
economic and cultural have in the world
not yet
in our development phase but
he accompanies transplant this is if
that this disparity
the people were looking the map of Brazil
Here you see that it is so Brazil
It has a thing about
30 intermediate the center transplants
per million population per year
but if we look at the Brazil region
by region there is a disparity
geographic which has in the world
also accompanies the disparity
socioeconomic region it is well
course in Brazil also in the southern region
and southeastern it has the color of
more developed countries states
United Europe and in the region nice
North and Northeast
mainly in the north too
least now this is
that this disparity
it can be corrected in some states
for example ceará Pernambuco
the commitment of the people in the program
transplant and harmony among
transplanters a public system
It causes the performance of the number of
transplants in Ceará in Pernambuco
is even better than in the state of
sao paulo is diluted but here
in that region
and here we are seeing here here
concerned is the Libyan Ethiopia is a
country we have a program of 11
acting in Ethiopia
I got there this morning this week
we did four transplants are
developing a program
transplants pet shop a country that has
a number of complications happens is
very poor
someone asks if it makes sense to
work of transport has sense to do
transplant work makes sense to make a
little because he transplants
complexity of the transplant it
It paves the way for other
situations with less complexity
It began to be made with the best for
best quality too
then it works well
difficulty but it surely will
able to get one day to one
transport model that we have here
in Brazil we will not get
resolving the transplant waiting list
once the transplant waiting list will be
always greater than the expected
people’s lives is increasing so
do not people get in line is
increasing
decreasing violent night thank god
It is decreasing then have much less
donor
we have four possibilities the
smell transplant would make a
transplant with organ one year
animal
this is more difficult to work out not
still managed to control the rejection
Now that control has a rejection
lot of viruses that live accommodated in
harmony in the room when people were
transferred the man does not know what will
to happen
and also do not know if your body
the body when he was beaten in
man if he will live the expectation
life I have a little bit 18
years and will live life expectancy
man
the drug was then let’s do it with
cells stem everyone speaking area
every time it appears on television
work made from stem cells
if you do a year from cells
trunk do not know why it was not done
even a blood cell is much more
easy with 171 blood someone wants
then donate or plants have very j
easier to make the hypothesis is
plant cell to produce a defeat
thing only
insulin only needs a sensor to
Today stem cells did not solve it
so I do not expect nor
xenotransplantation or stem cell will
be part of the mass of my life
biological
Another possibility is you do
engineering you take a sick organ
or bad strip all cells patient
Patients cell maintains the structure
later on it is provided with
normal cells of their own
body and will acquire the format
river is also hard to believe that
it will work well since it works
says is a transplant transplant
bone or if we take a fragment of
Bone fragment of a bone is bone
long leaves less 70 degrees all
They died a week but is 70 degrees
matrix that is one skeleton
basically formed by a wedge and is
only you put the cell’s own
one does not go there to take the place
It is rejected it but can not catch
it will not be will not be will not
It is rejected and will not be artificially
that we have way more
effective is the implementation of
Left ventricle
President already has people living with
the organ
It has been deployed for more than five years in
heart implants a heart
artificial implanted five more
years but still not a situation
so as part of everyday life in
one thing we can do to
help that depending on the situation
collective
the correction of the geographical disparity
also it does not depend on any any
new discovery in the mirror this year
transplantation does not depend on any
new discovery depends on a
collective collective will initiative
this is a membership campaign
Brazilian transplants if you want
be an organ donor the life of your
family and your family will understand if
to understand this as his last
desire is even a way for you
continue after death
contributing to society is a way
Simple to see his family his family
You will understand this as your last
I desire and will understand this as a
as you keep contributing
with society
I started talking when I started
saying that the transplant is much more
complex than than surgery or
that rejection or says the discovery
a new drug
I said it involves a series of
feelings involves feeling
we know enough and I will leave
these last 20 seconds
some images that clearly shows all
you will understand when I spoke well
the transplant involves around us and
It involves a lot of other things
complex as the various feelings and
you will see in these latest images
[Music]
the Portuguese school is close is is is
it is so
[Music]
Globo
[Music]
[Applause]
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