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The Gift of Adversity | Sophie Edelstein | TEDxYale


I ask of you the audience to envision a

gift it may have a big bow on top or be

pristinely wrapped the size does not

necessarily matter it could be large or

small

perhaps it looks something like this or

along these lines now that you have this

image in your mind and on the screen

you’re probably wondering what is inside

of this random box but before I tell you

what is actually inside I’m going to

give you a few hints first off it’s not

the game boy you asked for when you’re 8

years old and while it can’t purchase on

Amazon so most definitely does not

qualify for Amazon Prime and lastly well

there is no return to sender option

however it is a gift of impact it is not

a gift I would ever expect anyone else

to want in fact I didn’t want it at

first either but I’ve come to love it

for everything that it’s worth I call it

my gift of impact because it has led me

to some of the greatest successes and

realizations in my career thus far

successes that now act as a light at the

end of the tunnel in my constantly

changing life these gifts look something

like this completely obliterated

cartilage in both my hip joints much of

which I don’t have anymore

and this severely aunt Roberta femurs

basically for the first 16 years of my

life my lights did not sit straight in

my body and this femoral acetabular

impingement growths on both my hip

joints that restricted my femurs

removing properly my body therefore

affected by gait and lastly this a

genetic disorder by the name of Ahlers

Danlos syndrome these gifts soon turned

into this and this an array of pretty

awesome scars but I didn’t always view

them that way nowadays we asked research

scientists and physicians about that

light bulb moment when they realized

they wanted to go into a stem career

some may say well when I was in seventh

grade my science teacher showed me a

demonstration in class and I became a

Me’s by the reaction that occurred but

my story well it’s a little bit

different you see when I was a kid

I mean even more of a kid than I am now

I love science and engineering I loved

having my hands on things but I was

never able to find the motivation for

the research that I found today

everything in my childhood seemed pretty

much normal despite the fact that kids

at school made fun of me for the way I

ran I sort of just brush that off my

shoulder until one day when I was 13

years old and I was playing the game of

lacrosse sport I’d grown up playing I

was running straight down the field

about to shoot at the top right corner

of the goal when all of a sudden my hips

locked and I immediately fell to the

ground I could not get up I felt as if I

needed some sort of key to unlock my

hips a key I did not have at the time

shortly after this I found myself

sitting in countless doctors offices

week after week being forced to look in

an abundance of CT scans x-rays MRIs

even ultrasound studies copious amounts

of information was being thrown at me

and in that moment I decided I could

look at my situation one way or another

I could either like all this confusing

yet extremely interesting information go

in one ear not the other or I can

actually start listening and playing an

active role in my health I decided to

stick with option two surgeries began

quite promptly after this realization

and I found myself with a lot of free

time on my hands I mean I was sitting in

a hospital bed after all I decided to

put this free time to what I thought was

good use I began reading a plethora of

orthopedic and biomedical engineering

research journals highlighting

everything I understood an orange and

everything I didn’t understand it yellow

turned out that most of those pages were

covered in yellow but I didn’t let that

discourage me I mean I had the resources

after all I began I became that overly

annoying patient who asks way too many

questions but I think my doctors may

thank me for it later early on in my

high school career I worked on the

development of a two-part 3-d plinth

printed implant to treat internal

snapping hip syndrome and he bought the

lessons now that sounds like a mouthful

but I’ll break it down for you basically

I focused my study on female lessons not

only because I was one myself but

because one I was told

phase in my life where I thought that

being able to create an audible staff on

command with my hips was something worth

wanting to all of my friends and doctors

but more importantly research had found

that when female adolescents are going

through puberty their hips grow faster

than the rest of their body and then

this iliopsoas our hip flexor tendon

which sits right about here on my cup

joy is then forced to span a greater

surface area and becomes tight inflamed

and then snaps I realized that if I

could find a way to relieve the stress

of this iliopsoas off of those eminences

then I could ideally prevent the

snapping my research is actually quite

successful I computationally designed

tested and 3d printed a two-part implant

one located at the pelvis and one

located right below the greater

trochanter on my hip joint now like many

gifts mine always seems to keep on

giving after three years of treatment

quite close to home my doctors decided

that Sofie Adil’s see in the mystery

case was truly a mystery and there was

not much more they could do for me but

there was one place they had in mind and

it goes by the name of Boston Children’s

Hospital at the time I felt confused and

terrified and quite frankly abandoned I

mean I had never been given treatment

out of the Yale Network before but I

came to learn that Boston Children’s

Hospital was probably the best thing

that would ever happen to me I was

getting the health care I needed and I

was getting this amazing support system

in terms of research mentorship being

the science minded kid I was I had to do

all of my research I looked into the new

doctors new environment and just about

everything I was getting myself into

even if I generally didn’t know at those

points in time during my excessive

research I came across an article in The

New York Times titled doctors experiment

with new ways of fixing the ACL in my

mind I thought orthopedic score but it

was even better when I came to realize

that my own doctors were the ones behind

this new treatment the team that Boston

Children’s Hospital had identified that

the ACL in the knee does not heal

naturally due to a lack of blood supply

in the area that would inevitably send

signals throughout the rest of the body

to initiate regeneration however if you

can find a way stabilize the blood in

the area then a clot forms and those

signals can be sent

therefore encouraging her generation I

recognize that the same thing happens

with yah sevate labrum in the hip joint

so if I could develop a scaffold with

similar properties to that in the bridge

in hand Stacy Elton I and many others

could avoid the countless favorite

repair surgeries and allow our bodies do

what they do best which is of course

heal you see we have blood which is this

great stimulant for healing which comes

straight from the patient’s body and

this scaffold that I worked on in the

lab which has the ability to hold the

blood in the wound site therefore

activating the platelets and then those

two things together form a stable clot

that solidifies which has the ability to

encourage cell engross proliferation and

even tissue we feel like now my research

adds that presented here sounds pretty

much perfect

but I can assure you that it was far

from that I met a multitude of

roadblocks along the way and there were

many times when I wanted to give up just

like many scientists would but I had

this false idea in my mind that if I

gave up well then it was fair game for

my doctors to give up on me something I

had always feared but that is not my

point here my point is that I do not

rate my success on the awards I’ve won

international science competitions for

this research I just described or even

the fact that I’m standing talking to

all of you right now I rate my success

on the feeling of walking out of the lab

at the end of a long tiring and

confusing day and knowing that there are

research scientists in positions across

the globe working on similar things as I

am to better my life and the life of

many others if I can help out too then

why not I’ve come to realize that

there’s a very very close tie between my

research and my health challenges I know

I will not be better tomorrow or next

month or maybe even next year but when

is there a day we walk into the lab and

sit down at the bench and say today I am

going to cure a colon cancer we don’t

it is simply impractical and irrational

we have been working on a cure for colon

cancer for the last 10 to 15 years and

still have not found it but there will

be a day we do find it just like there

will be a day where I will be able to

walk up a single fly

Aires and not feel as if my legs are

going to collapse from underneath me it

is research that will make that possible

it is research that has allowed me to

stand on the stage for the last 10

minutes talking all of you without

eating my cane it is research that

brought tears to my eyes at the sight of

two straight legs for the first time in

my life it is research that has allowed

me to learn how to walk again and it is

research that has acted as that light at

the end of the tunnel you do not have to

be a math or science genius to play an

active role in your health but if you

find something you are confident about

it’ll act as the force behind you

towards your success whether that be in

developing a more positive or optimistic

attitude these gifts are not supposed to

break you down they’re supposed to build

you up as cliche as that sounds these

gifts help me realize that I love

science and I love engineering and I

love helping people at least that’s how

I’ve managed to see it thank you very

much

[Applause] [Music]

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