Translator: Sebastian Betti
And here I come with my story, a story that started 25, 26 years ago.
There was no Internet, for us to appear.
I was a doctor in a public hospital in the city of Rosario
and towards immunodermatology
and a query was presented to us that morning, which was an almost fictional situation.
It was a couple that could not have babies and how they were anxious about that paternity
They decide to adopt a creature that delighted in that marriage.
And after about 5 years, more or less, the mother becomes pregnant.
The mother becomes pregnant, the family rebounds.
And a child is born, a little girl very white, very blonde.
And the little brother who was 6 years old, with a pretty dark complexion.
The second is always an event of discord in one place.
And more, if there are 6 years apart, and this creature cries, screams,
he is hungry, and he makes his needs and all that demands
a series of enormous care.
And there is another one who is 6 years old who suddenly sees that there is an intruder
that he takes all the care he had.
The issue is that, in this compare, he sees that there is a creature
that demands a lot of care, very white, very blonde and he does not like that.
And what does this creature do, which is why it came to the consultation?
A vitiligo.
And a vitiligo is depigmenting the skin and is an autoimmune disease.
It is a disease where the defensive cells
they are wrong and attack some cells that produce melanin,
the pigment of the skin and that, when sunbathing,
we get dark.
You look at that, and it says how do we explain this?
A fact that hits, that hurts, because it says in some way
emotions have come down to the flesh, and emotions are before reason
and a 6 year old boy is much more emotion than reason.
And one says, you really think you know things when in reality, you know very little.
And that’s why I say, there was no Internet and then we said:
How can this happen? For this to happen, there must be
a communication between the brain and the immune system.
The first approach, the first idea.
And that was the origin of a passion, at least passion that one
motivated him and moved him.
And we said and well, and why the immune system
Would I have to communicate to the brain?
And one says, if you are standing on that corner and suddenly see
a truck approaching by burning a black smoke
Does anyone stay in that place or withdraw?
No, obviously we retired; the brain says “it’s not good for you”.
And if the brain can detect is black smoke that comes from outside,
It would also be good to detect a black smoke that comes from inside.
Why? Because there is a threat.
And what is that black smoke that comes from inside?
Inflammation, the old inflammation: blush, tumor, heat and pain.
Celso, 100 AD, that old.
Why does there have to be inflammation? Because they have attacked us.
These people have attacked us, we have, more or less,
three million years and the neighbors that attack us
They are 2000 million years old,
so they know a lot more molecular biology than we do,
they passed many more subjects and they attack us.
And we, how do we defend ourselves? Inflating to mount an answer.
But evidently, this sign of inflammation
must reach the brain to warn, if you want to give it a name,
“There’s a mess in the henhouse.”
How does that come? Well, throughout these 25 years
we saw that a lot of this information comes from nerves
and another is what circulates in the blood and reaches the brain
the brain makes contact and what does it do?
By nerves, and by circulation through hormones
try to put a fine tuning
so that the answer is as effective as possible.
What is the response rush? Eliminate the aggressor, repair the damage,
and leave in the best possible way.
In this way of defending ourselves, we call it the neuroendocrine network:
Neural and endocrine.
What was it for? To defend ourselves and optimize answers.
At a time when we were exposed to very aggressive germs
and that the life of man will have been 20 years, it was not much more,
It was not much more; that is, we were selected and adapted for this.
But the history of man, near the Neolithic
if you want, 10,000 years BC, more or less over there,
changed, there was an important socio-economic cultural development
we enter the scene, with our great father and teacher
that was Hippocrates, on the island of Kos in the Aegean, 300 years BC
And medicine, and improvements in living conditions
He made man more lasting.
The man lasted longer and, when it lasted longer, he had time to have diseases
for which there was no programming.
So, now I can have a degenerative disease,
I can have an autoimmune disease, I can have an infection
He will not kill me, but he is silent, he goes slowly, he has no hurry,
and I have that.
And I answer With what do I respond?
With the mechanism that we had when we had a very bad time.
That has been the leitmotiv of the defense.
The issue is that we are not adapted to chronicity
to make those great answers we did in those lost years
of prehistory; then when the system
has a chronic stimulation starts to make mistakes.
How could we call that I now had a chronic stimulation?
Well, it occurred to me to give it a name: “immunological stress”.
I could tell the patient, you are stressed immunologically
which means you can say that you have a viral, silent infection,
but he has it, or he has a degenerative disorder,
or that has a disease similar to being autoimmune that generates a patent
of chronic inflammation, which does not bother too much, but it is.
And as it is, the neuroendocrine system responds
but in a not so successful way.
And since it is not so successful, they begin to appear in this person
a series of sequels …
of chronic inflammatory disease,
fueled by this neuroendocrine response.
And what sequels are they? And some may have anorexia,
others may have cachexia, and others in reverse, increased adiposity
others may have hypertension, blessed metabolic syndrome,
cardiovascular alterations.
Are we all going to have this? No, peace of mind,
tranquility not.
Each one will have a very particular rearrangement depending on the agent
that triggers it and the vulnerability that I have in each type of organ.
The truth is that if immune stress persists
something is going to happen, sooner or later
So I say if it’s stress. Stress what is it?
Stress is pressure on a body; That is the definition of stress.
Then, to represent it, I brought a ribbon.
And what is this tape? This tape is quiet,
living his life, but now it occurs to me
Stress it to the tape.
In the Paleolithic the stress was so great
that the tape came to break.
Not today. Today the tape has a slow stress,
chronic, but it deforms.
Where are we going with the tape?
That each one of us could want to dare to check
how is your tape,
Can do it? Yes of course.
Some I can do for myself, how I eat, how I sleep,
heart rate, respiratory rate,
how is my mood
And some with the help of us, we could call it, the health team.
And I can make blood determinations of blood chemistry.
Some is a well-known, measurement of plasma cortisol
It gives an idea of how my stress goes, and also the adrenaline
which is a pretty well known word.
If I understand that my tape is under tension,
What do I have to do? I have to ask for help.
I have to ask for help, lower my omnipotence
and someone to take care of this question. And who is that? The health team
And there we will see how we can act.
The person who defined it with all the letters
it was Hippocrates, who said
that the individual has within himself a natural healing force
vis medicatrix naturae.
And for that natural healing force to start and get going,
the doctor or the health team had to help him
with physical and psychological means and in psychological ones this is the teacher,
for the psychological mechanisms to work, the soul had to rest
in consolation and hope.
And now we have the great health teams.
I would dare to say, since we are on advice,
also learn to reconcile it with our limits.
And, if necessary, laugh at our sorrows.
If we do not handle it, this immune stress will also give
disorders of behavior, and moods.
And after 25 years of working something we’ve seen, something of the puzzle
is beginning to be clarified, that mood disorders
they also come back on the immune system and show up with aggression
that would answer that story, that child of 6 years, 1990.
Thank you very much.
(Applause)
And here I come with my story, a story that started 25, 26 years ago.
There was no Internet, for us to appear.
I was a doctor in a public hospital in the city of Rosario
and towards immunodermatology
and a query was presented to us that morning, which was an almost fictional situation.
It was a couple that could not have babies and how they were anxious about that paternity
They decide to adopt a creature that delighted in that marriage.
And after about 5 years, more or less, the mother becomes pregnant.
The mother becomes pregnant, the family rebounds.
And a child is born, a little girl very white, very blonde.
And the little brother who was 6 years old, with a pretty dark complexion.
The second is always an event of discord in one place.
And more, if there are 6 years apart, and this creature cries, screams,
he is hungry, and he makes his needs and all that demands
a series of enormous care.
And there is another one who is 6 years old who suddenly sees that there is an intruder
that he takes all the care he had.
The issue is that, in this compare, he sees that there is a creature
that demands a lot of care, very white, very blonde and he does not like that.
And what does this creature do, which is why it came to the consultation?
A vitiligo.
And a vitiligo is depigmenting the skin and is an autoimmune disease.
It is a disease where the defensive cells
they are wrong and attack some cells that produce melanin,
the pigment of the skin and that, when sunbathing,
we get dark.
You look at that, and it says how do we explain this?
A fact that hits, that hurts, because it says in some way
emotions have come down to the flesh, and emotions are before reason
and a 6 year old boy is much more emotion than reason.
And one says, you really think you know things when in reality, you know very little.
And that’s why I say, there was no Internet and then we said:
How can this happen? For this to happen, there must be
a communication between the brain and the immune system.
The first approach, the first idea.
And that was the origin of a passion, at least passion that one
motivated him and moved him.
And we said and well, and why the immune system
Would I have to communicate to the brain?
And one says, if you are standing on that corner and suddenly see
a truck approaching by burning a black smoke
Does anyone stay in that place or withdraw?
No, obviously we retired; the brain says “it’s not good for you”.
And if the brain can detect is black smoke that comes from outside,
It would also be good to detect a black smoke that comes from inside.
Why? Because there is a threat.
And what is that black smoke that comes from inside?
Inflammation, the old inflammation: blush, tumor, heat and pain.
Celso, 100 AD, that old.
Why does there have to be inflammation? Because they have attacked us.
These people have attacked us, we have, more or less,
three million years and the neighbors that attack us
They are 2000 million years old,
so they know a lot more molecular biology than we do,
they passed many more subjects and they attack us.
And we, how do we defend ourselves? Inflating to mount an answer.
But evidently, this sign of inflammation
must reach the brain to warn, if you want to give it a name,
“There’s a mess in the henhouse.”
How does that come? Well, throughout these 25 years
we saw that a lot of this information comes from nerves
and another is what circulates in the blood and reaches the brain
the brain makes contact and what does it do?
By nerves, and by circulation through hormones
try to put a fine tuning
so that the answer is as effective as possible.
What is the response rush? Eliminate the aggressor, repair the damage,
and leave in the best possible way.
In this way of defending ourselves, we call it the neuroendocrine network:
Neural and endocrine.
What was it for? To defend ourselves and optimize answers.
At a time when we were exposed to very aggressive germs
and that the life of man will have been 20 years, it was not much more,
It was not much more; that is, we were selected and adapted for this.
But the history of man, near the Neolithic
if you want, 10,000 years BC, more or less over there,
changed, there was an important socio-economic cultural development
we enter the scene, with our great father and teacher
that was Hippocrates, on the island of Kos in the Aegean, 300 years BC
And medicine, and improvements in living conditions
He made man more lasting.
The man lasted longer and, when it lasted longer, he had time to have diseases
for which there was no programming.
So, now I can have a degenerative disease,
I can have an autoimmune disease, I can have an infection
He will not kill me, but he is silent, he goes slowly, he has no hurry,
and I have that.
And I answer With what do I respond?
With the mechanism that we had when we had a very bad time.
That has been the leitmotiv of the defense.
The issue is that we are not adapted to chronicity
to make those great answers we did in those lost years
of prehistory; then when the system
has a chronic stimulation starts to make mistakes.
How could we call that I now had a chronic stimulation?
Well, it occurred to me to give it a name: “immunological stress”.
I could tell the patient, you are stressed immunologically
which means you can say that you have a viral, silent infection,
but he has it, or he has a degenerative disorder,
or that has a disease similar to being autoimmune that generates a patent
of chronic inflammation, which does not bother too much, but it is.
And as it is, the neuroendocrine system responds
but in a not so successful way.
And since it is not so successful, they begin to appear in this person
a series of sequels …
of chronic inflammatory disease,
fueled by this neuroendocrine response.
And what sequels are they? And some may have anorexia,
others may have cachexia, and others in reverse, increased adiposity
others may have hypertension, blessed metabolic syndrome,
cardiovascular alterations.
Are we all going to have this? No, peace of mind,
tranquility not.
Each one will have a very particular rearrangement depending on the agent
that triggers it and the vulnerability that I have in each type of organ.
The truth is that if immune stress persists
something is going to happen, sooner or later
So I say if it’s stress. Stress what is it?
Stress is pressure on a body; That is the definition of stress.
Then, to represent it, I brought a ribbon.
And what is this tape? This tape is quiet,
living his life, but now it occurs to me
Stress it to the tape.
In the Paleolithic the stress was so great
that the tape came to break.
Not today. Today the tape has a slow stress,
chronic, but it deforms.
Where are we going with the tape?
That each one of us could want to dare to check
how is your tape,
Can do it? Yes of course.
Some I can do for myself, how I eat, how I sleep,
heart rate, respiratory rate,
how is my mood
And some with the help of us, we could call it, the health team.
And I can make blood determinations of blood chemistry.
Some is a well-known, measurement of plasma cortisol
It gives an idea of how my stress goes, and also the adrenaline
which is a pretty well known word.
If I understand that my tape is under tension,
What do I have to do? I have to ask for help.
I have to ask for help, lower my omnipotence
and someone to take care of this question. And who is that? The health team
And there we will see how we can act.
The person who defined it with all the letters
it was Hippocrates, who said
that the individual has within himself a natural healing force
vis medicatrix naturae.
And for that natural healing force to start and get going,
the doctor or the health team had to help him
with physical and psychological means and in psychological ones this is the teacher,
for the psychological mechanisms to work, the soul had to rest
in consolation and hope.
And now we have the great health teams.
I would dare to say, since we are on advice,
also learn to reconcile it with our limits.
And, if necessary, laugh at our sorrows.
If we do not handle it, this immune stress will also give
disorders of behavior, and moods.
And after 25 years of working something we’ve seen, something of the puzzle
is beginning to be clarified, that mood disorders
they also come back on the immune system and show up with aggression
that would answer that story, that child of 6 years, 1990.
Thank you very much.
(Applause)
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