[Music]
where are we from this old dream of
the humanity of the fountain of youth
that finally lucas cranach represented
like this source
where it was sufficient to bathe or to
to drink to see disappear at once
diseases where aging is aging
de leon this Spanish browser does not have
found of course the fountain of youth
but only he discovered a
part of america florida
so finally that’s his today
these adventurers of modern times is
what scientists are not
become is what research on the
aging today we
allow to consider this fountain of
youth and do where are we
well when you’re interested in
aging
finally why be interested in
aging things are he puts
maybe inescapable well maybe
because well when you
older, well it’s also because
that your family and that maybe
well it could avoid this kind of
situation no of course I’m kidding but
maybe gentlemen but on seniors
maybe it’s not too late and
that with a little bit of sport if you
follow the example of this person you
may be able to find your
musculature of young men what
would suggest that ultimately this
aging may not be as
inescapable as one might think
so what we know in any case is
that life expectancy has not stopped
grow in recent centuries
she doubled in the last century and
today we win every year
three months of life expectancy
so of course even if certain numbers
epidemiologists tells us that
maybe we’ve reached
the age limit
the whole question is all the same
to know if this curve will bend or
alright if we will continue to
progress in this way
if so, and well we can
hope in 2050 to have a hope of
life all about 120 years old then
today in women she is from
85 and men 79
what do biologists tell us that we
say the researchers and well you
understand that when one is interested in
aging
well we use models
animals in the labs so we
use for example these little glasses
who or under that fly which due
from his short his short life and well we
allows to explore strategies on
the anti age or again and well this
mouse which is a common animal of
laboratory that despite everything is a
mammal and who gets closer to the man
so it’s with this little green that in
the 90s on the west coast of
United States
cynthia kenyon has identified that he
existed aging genes and
that if we inactivate and sgen and well we
could increase the longevity of this
animal and by combining the inactivation of
many of his genes well
today we are able to increase
eight times the longevity of this animal is
in good health
I fly a similar strategy
allows to increase four times the
longevity of this animal then of course
to try to understand the
aging we do not just do that
for example, we try to compare
species with different longevities
and this is the case for example
for this rake who live a thirty
of years while the common rat him a
life that three years what are the genes
who are involved what are the
differences all that drives the researchers
researchers and then sometimes in a
same species and well we can have
big differences in longevity
this is the case for the crutch for a
worker and well the life of
a few months while for the queen
well she is 5 years the only one
difference while these animals at
departure are clones is well that’s
that she has a different way of life
the workwoman work while the queen is
rests and she keeps all through her
life a fertility capacity that has only
the more the napa the worker the only
difference is there actually
feeding then at humans we
age also at speeds
different
it’s in Corsican is particularly
dramatic for those individuals who are
with pathologies of
early aging since they are
likely to recap all
stages of aging in a few
years and die of old age at 13
what we know today is that the
aging the share of young people in
our longevity and well and just about
25% the rest the other 75 percent
Well, that’s our way of
life our diet
no stress and it’s rather a good
new since probably on that one
can act
so why are we getting older
finally why our bodies
age why our fabrics
are getting older and well it’s starting from
our cells are aging
throughout our life our cells
are subject to many stresses that
are likely to damage them the
cell to possible mechanisms for
to repair
it’s damage when
the stresses are too violent well the
cell can decide to destroy itself
it’s cell death and there we see
decrease the number of cells in our
tissues when it can repair it’s
pity
well she still keeps some
number of traces and she loses little to
small its ability to regenerate note if
the cell is aging it is said that it is
deprogram or again and then it becomes
much more dramatic is when
the cell can no longer destroy itself and
that it becomes senescent what is it
that means seven cells
senescent and well she stops from
to divide
and then unfortunately she starts to
synthesize a whole set of factors
in the environment of our fabric that
are likely to disrupt
to age our tissues that we know
now is that well these
cells they accumulate these cells
senescent they accumulate with
age largely on our tissues and
they are often associated with
pathologies that are related to age also
osteoarthritis osteoporosis well that the
sarcopenia muscle wasting or even
cataract and many others then with
what I just told you can
imagine and the researchers imagined it
to be able to have a number
interventions to overcome this
aging
we can possibly try to
delay this senescence
we can eventually delete these
senescent cells if possible
and then we can be stimulated these
old cells that are not
capable of who are no longer able to
regenerate our tissues or even tried
possibly reprogram them
since they are deprogrammed then
today perhaps among you there is
people who have had a
prescription for example for diabetes
type 2
one when one is suffering from this
pathology
well we give metformin the
metformin it’s a molecule that can
delay aging and especially
who will delay senescence
when for example cholesterol
we are going to take statins that are already
small molecules of drugs and
which will also have a positive effect and
delaying senescence so eventually
already you take a number of
medicines to treat your pathologies
age-related if you have 5 and without
know it then delay senescence
may not be enough maybe
that we can try to destroy these cells
senescent and that’s what the
researchers did I use now
small molecules that will wake up
in the senescent cell the capacity
to destroy himself
we call it olitic scenery ago
a whole set of molecules that
are starting to come out and that are coming soon
in clinical trial and you see the
difference in these mice in
done when treating these mice with
these molecules that destroy the
senescent cells and well these mice
no more age-related pathologies
cataract and shifted no more than 2 during
dose of muscle wasting and in addition
they live 30% more and in good
health so tried to imagine if one
transposed saalum so maybe we
can also try to stimulate his
old cells to regenerate everything from
same fabric and it was done also by
researchers by connecting a mouse
young and an elderly mouse by the
blood circulation and what they have
identified is that well it was
sufficient to be able to improve the
muscle regeneration of the mouse
elderly but also to restructure his
heart that were dilated by age and
even recovered the spatial memory that
was lost
in this animal seeing even old
brain cells make new
connections to improve the
brain function then
today in the united states using
of plasma of young people and well a
clinical trial was launched to see
how far we could with that
young cell plasma and of course
people over 60
improve their physiology and make
that they have fewer related pathologies
at age and especially a test is planned
on Alzheimer’s disease
so to try to go further
to try to see how we could
could regenerate tissues and well one
sometimes draws inspiration from nature in the
nature there are abilities
exceptional regeneration
example you know it all
salamander you cut him a limb
wanted to cut the tail that regenerates those
small aquarium fish the fish
zebra well when we cut him a
third of the heart it regenerates sucker the
planère when cutting and an
dozens of pieces she will make ten
planets books and well she redid
individuals when she feels like it
we now know that these animals have
kept the embryonic abilities is
and not eg they kept
stem cells in the case of the
planère for example they kept
embryonic stem cells that are
able to redo all the fabrics but
in the adult state and at the hydra well
she did not keep them but she is
able to re manufactured then this
jellyfish also probably use these
stem cells
since you see like in this movie of
benjamin button
well she found the way
when she grew older not only
destroy those aging cells and
once she has reproduced and
then she’s just keeping
stem cells that are capable
remaking the individual
she does cycles infinitely of
the kind is probably good that this
jellyfish is immortal then in humans
we have stem cells
embryonic
within a few days of life we can
isolate cultivate they are immortal
and they are going that capacity
exceptional to remake any
what type of fabric since they are going
make the embryo then of course there
have to remove one’s cells from an embryo
ethically it is not satisfactory
but in recent years we can
take a cell from an individual and
reprogrammed it to convert it into a
cell equivalent to that of strains
embryonic with all the same with
all skins its potentialities and
so in my laboratory we are
are said that maybe with this
strategy to reprogram the cells
we could reprogram cells
aging are from cells
centenarians of senescent cells
and that’s what we did
have converted his cells into cells
embryonic stem we have them
makes the time go up we have
passage erase the marks of the
aging and we could streets
differentiate into various cells
skin cells we were part
from these places for today we can
follow these cells you see it’s
nascent who does not move much who
secrete those factors that are not
able to regenerate tissues and
when we program them for re
differentiates that’s what they do to
again she divides
quickly they are a physiology
juvenile they are able to
restore tissue regeneration
so today we do not leave
necessarily neither that of the skin can we
to make from your blood cells
and then we can differentiate them into
something else and you see for example
in the box we can form
heart cells that then beat that
open doors
amazing opportunities in medicine
amazing and of course today we
can and science is here to do it
use these cells as
drugs inject them make the
cell therapy to correct by
example an age-related infarction on
can also use them to recolonize
a heart with old cells on
which one would have deleted these cells
it’s happening today in
labs and reformed a choir
functional or even use
animals it’s already started to make
develop a human heart that one
can then be grafted
so after this avalanche of two
technologies that allow either
delete only cells
senescent to make our tissues
improves and that eventually delays
age-related pathologies or
reprogrammed our old cells
the regrets made or even make them
organs and well you see that the
science has made a lot of progress on
aging and we can hope
a lot today
the digital giants have seized
of this quest for grail is for example
google is good at creating a company
calicoes that will inject 1.5 billion
dollars to kill death facebook mark
zuckerbeg rezzouk down to zuckerberg
sorry and well 3 billion dollars
to eradicate all diseases
so my belief is that we are
at a turning point in our history and that
probably the 21st century should only
not see this life expectancy curve
to bow down and for those who would like
to go even further and well I will do
a pirouette to tell you that
eternity is long but especially at the
end thank you
[Applause]
[Music]
where are we from this old dream of
the humanity of the fountain of youth
that finally lucas cranach represented
like this source
where it was sufficient to bathe or to
to drink to see disappear at once
diseases where aging is aging
de leon this Spanish browser does not have
found of course the fountain of youth
but only he discovered a
part of america florida
so finally that’s his today
these adventurers of modern times is
what scientists are not
become is what research on the
aging today we
allow to consider this fountain of
youth and do where are we
well when you’re interested in
aging
finally why be interested in
aging things are he puts
maybe inescapable well maybe
because well when you
older, well it’s also because
that your family and that maybe
well it could avoid this kind of
situation no of course I’m kidding but
maybe gentlemen but on seniors
maybe it’s not too late and
that with a little bit of sport if you
follow the example of this person you
may be able to find your
musculature of young men what
would suggest that ultimately this
aging may not be as
inescapable as one might think
so what we know in any case is
that life expectancy has not stopped
grow in recent centuries
she doubled in the last century and
today we win every year
three months of life expectancy
so of course even if certain numbers
epidemiologists tells us that
maybe we’ve reached
the age limit
the whole question is all the same
to know if this curve will bend or
alright if we will continue to
progress in this way
if so, and well we can
hope in 2050 to have a hope of
life all about 120 years old then
today in women she is from
85 and men 79
what do biologists tell us that we
say the researchers and well you
understand that when one is interested in
aging
well we use models
animals in the labs so we
use for example these little glasses
who or under that fly which due
from his short his short life and well we
allows to explore strategies on
the anti age or again and well this
mouse which is a common animal of
laboratory that despite everything is a
mammal and who gets closer to the man
so it’s with this little green that in
the 90s on the west coast of
United States
cynthia kenyon has identified that he
existed aging genes and
that if we inactivate and sgen and well we
could increase the longevity of this
animal and by combining the inactivation of
many of his genes well
today we are able to increase
eight times the longevity of this animal is
in good health
I fly a similar strategy
allows to increase four times the
longevity of this animal then of course
to try to understand the
aging we do not just do that
for example, we try to compare
species with different longevities
and this is the case for example
for this rake who live a thirty
of years while the common rat him a
life that three years what are the genes
who are involved what are the
differences all that drives the researchers
researchers and then sometimes in a
same species and well we can have
big differences in longevity
this is the case for the crutch for a
worker and well the life of
a few months while for the queen
well she is 5 years the only one
difference while these animals at
departure are clones is well that’s
that she has a different way of life
the workwoman work while the queen is
rests and she keeps all through her
life a fertility capacity that has only
the more the napa the worker the only
difference is there actually
feeding then at humans we
age also at speeds
different
it’s in Corsican is particularly
dramatic for those individuals who are
with pathologies of
early aging since they are
likely to recap all
stages of aging in a few
years and die of old age at 13
what we know today is that the
aging the share of young people in
our longevity and well and just about
25% the rest the other 75 percent
Well, that’s our way of
life our diet
no stress and it’s rather a good
new since probably on that one
can act
so why are we getting older
finally why our bodies
age why our fabrics
are getting older and well it’s starting from
our cells are aging
throughout our life our cells
are subject to many stresses that
are likely to damage them the
cell to possible mechanisms for
to repair
it’s damage when
the stresses are too violent well the
cell can decide to destroy itself
it’s cell death and there we see
decrease the number of cells in our
tissues when it can repair it’s
pity
well she still keeps some
number of traces and she loses little to
small its ability to regenerate note if
the cell is aging it is said that it is
deprogram or again and then it becomes
much more dramatic is when
the cell can no longer destroy itself and
that it becomes senescent what is it
that means seven cells
senescent and well she stops from
to divide
and then unfortunately she starts to
synthesize a whole set of factors
in the environment of our fabric that
are likely to disrupt
to age our tissues that we know
now is that well these
cells they accumulate these cells
senescent they accumulate with
age largely on our tissues and
they are often associated with
pathologies that are related to age also
osteoarthritis osteoporosis well that the
sarcopenia muscle wasting or even
cataract and many others then with
what I just told you can
imagine and the researchers imagined it
to be able to have a number
interventions to overcome this
aging
we can possibly try to
delay this senescence
we can eventually delete these
senescent cells if possible
and then we can be stimulated these
old cells that are not
capable of who are no longer able to
regenerate our tissues or even tried
possibly reprogram them
since they are deprogrammed then
today perhaps among you there is
people who have had a
prescription for example for diabetes
type 2
one when one is suffering from this
pathology
well we give metformin the
metformin it’s a molecule that can
delay aging and especially
who will delay senescence
when for example cholesterol
we are going to take statins that are already
small molecules of drugs and
which will also have a positive effect and
delaying senescence so eventually
already you take a number of
medicines to treat your pathologies
age-related if you have 5 and without
know it then delay senescence
may not be enough maybe
that we can try to destroy these cells
senescent and that’s what the
researchers did I use now
small molecules that will wake up
in the senescent cell the capacity
to destroy himself
we call it olitic scenery ago
a whole set of molecules that
are starting to come out and that are coming soon
in clinical trial and you see the
difference in these mice in
done when treating these mice with
these molecules that destroy the
senescent cells and well these mice
no more age-related pathologies
cataract and shifted no more than 2 during
dose of muscle wasting and in addition
they live 30% more and in good
health so tried to imagine if one
transposed saalum so maybe we
can also try to stimulate his
old cells to regenerate everything from
same fabric and it was done also by
researchers by connecting a mouse
young and an elderly mouse by the
blood circulation and what they have
identified is that well it was
sufficient to be able to improve the
muscle regeneration of the mouse
elderly but also to restructure his
heart that were dilated by age and
even recovered the spatial memory that
was lost
in this animal seeing even old
brain cells make new
connections to improve the
brain function then
today in the united states using
of plasma of young people and well a
clinical trial was launched to see
how far we could with that
young cell plasma and of course
people over 60
improve their physiology and make
that they have fewer related pathologies
at age and especially a test is planned
on Alzheimer’s disease
so to try to go further
to try to see how we could
could regenerate tissues and well one
sometimes draws inspiration from nature in the
nature there are abilities
exceptional regeneration
example you know it all
salamander you cut him a limb
wanted to cut the tail that regenerates those
small aquarium fish the fish
zebra well when we cut him a
third of the heart it regenerates sucker the
planère when cutting and an
dozens of pieces she will make ten
planets books and well she redid
individuals when she feels like it
we now know that these animals have
kept the embryonic abilities is
and not eg they kept
stem cells in the case of the
planère for example they kept
embryonic stem cells that are
able to redo all the fabrics but
in the adult state and at the hydra well
she did not keep them but she is
able to re manufactured then this
jellyfish also probably use these
stem cells
since you see like in this movie of
benjamin button
well she found the way
when she grew older not only
destroy those aging cells and
once she has reproduced and
then she’s just keeping
stem cells that are capable
remaking the individual
she does cycles infinitely of
the kind is probably good that this
jellyfish is immortal then in humans
we have stem cells
embryonic
within a few days of life we can
isolate cultivate they are immortal
and they are going that capacity
exceptional to remake any
what type of fabric since they are going
make the embryo then of course there
have to remove one’s cells from an embryo
ethically it is not satisfactory
but in recent years we can
take a cell from an individual and
reprogrammed it to convert it into a
cell equivalent to that of strains
embryonic with all the same with
all skins its potentialities and
so in my laboratory we are
are said that maybe with this
strategy to reprogram the cells
we could reprogram cells
aging are from cells
centenarians of senescent cells
and that’s what we did
have converted his cells into cells
embryonic stem we have them
makes the time go up we have
passage erase the marks of the
aging and we could streets
differentiate into various cells
skin cells we were part
from these places for today we can
follow these cells you see it’s
nascent who does not move much who
secrete those factors that are not
able to regenerate tissues and
when we program them for re
differentiates that’s what they do to
again she divides
quickly they are a physiology
juvenile they are able to
restore tissue regeneration
so today we do not leave
necessarily neither that of the skin can we
to make from your blood cells
and then we can differentiate them into
something else and you see for example
in the box we can form
heart cells that then beat that
open doors
amazing opportunities in medicine
amazing and of course today we
can and science is here to do it
use these cells as
drugs inject them make the
cell therapy to correct by
example an age-related infarction on
can also use them to recolonize
a heart with old cells on
which one would have deleted these cells
it’s happening today in
labs and reformed a choir
functional or even use
animals it’s already started to make
develop a human heart that one
can then be grafted
so after this avalanche of two
technologies that allow either
delete only cells
senescent to make our tissues
improves and that eventually delays
age-related pathologies or
reprogrammed our old cells
the regrets made or even make them
organs and well you see that the
science has made a lot of progress on
aging and we can hope
a lot today
the digital giants have seized
of this quest for grail is for example
google is good at creating a company
calicoes that will inject 1.5 billion
dollars to kill death facebook mark
zuckerbeg rezzouk down to zuckerberg
sorry and well 3 billion dollars
to eradicate all diseases
so my belief is that we are
at a turning point in our history and that
probably the 21st century should only
not see this life expectancy curve
to bow down and for those who would like
to go even further and well I will do
a pirouette to tell you that
eternity is long but especially at the
end thank you
[Applause]
[Music]
Please follow and like us: