[Music]
I must have been 14 maybe 15 years old
as I left school as always I know ask me
why I was making sure my tight worst my
tie was straight and I had no stains my
school uniform but the next thing I
remember hearing is grandad is in the
hospital he had a heart attack I will
never forget he was a Tuesday and on
every Tuesday I used to go running with
my grandfather this is my grandfather
that survived war he’s been in military
deployments and he survived extremism
but at that moment my grandfather was
being killed by his own heart I went
running straight away to the hospital in
eyes as I entered the hospital I saw him
sitting pale sick and worried in a
hospital bed next to him there was a
pile of papers and these papers had a
drawing of a heart and notes from his
surgeon the surgeon told me I’m going to
patch your grandfather’s heart tomorrow
morning but he said to patch it up not
mend it and I really wondered what was
going to happen to my grandfather and
actually at that moment I never really
paid much attention to hearts any hearts
even my own let me ask you a question
how many of you have been checking your
heart lately
raise your hands if you have checked
your heart well this is reflective that
we really don’t pay much attention to
our hearts in fact we very evil to our
hearts 95% of what all vascular disease
is preventable a few changes in our diet
our lifestyle increased heart an
increased exercise would really make us
better
in fact we are so Cruella Deville that
60% of us in this room will die for
cardiovascular disease or is
ramifications so I thought as a young
graduate in 2007 that I was going to do
something about it and early 2008 I
really despaired and I was looking out
of the window at University College
London labs and I saw the building in
front it was full of cement and building
works and I saw they were building the
London Center for nanotechnology so I
looked at it and I thought my stem cells
and I’m really not going to fix this
problem so I’d need to do something
about it why not use nanotechnology to
sort this problem and I really thought I
was sleep deprived going insane because
I was totally ignorant I just actually
learnt the word nanotechnology I had no
idea what that was so the next thing I
know a few months later a few too many
emails I set up a system by which I
would research and for distant areas
totally different areas of research
involving at least six different
universities in three different
countries and I tell you held two
conference calls and direct flights I
wanted to create a system to deliver
drugs in stem cells and get these to go
into your broken heart and really help
it to be mended the system would consist
of something brand new a totally novel
nanoparticle or none of thing I used to
call it and we would be able to deliver
delivered drugs with it so these cells
which we were putting in very hostile
situations with actually solved at the
time the major problems were one you
couldn’t really get stem cells to
survive in an impacted myocardium
because it was a really hostile area was
a bit like putting these stem cells into
a warzone and number two we really
didn’t have a system that could deliver
drugs and be trackable over time so I
thought let’s do this and in fact we
created a system by which it was all
biocompatible and ideal for human usage
obviously that was so 2030 right often
simple ideas involved very complex
experimentation
we went all the way from developing
physical instruments to surgical
apparatus
I used my initiative and I was
definitely not afraid can you we do it
yes we can’t and a few years later that
day had arrived the day which the data
show we could do it I really remember it
I was in Northville in Finland I spent
the whole winter in there and I had not
seen any natural daylight for a long
time in fact I was really really looking
forward to the good weather in London
ironic isn’t it
so just before I left and I boarded that
flight I got a call from a supervisor
saying well done I never thought you
would do it you’ve got so lucky this is
pretty much impossible and just a note
on luck I don’t believe in luck um luck
is a very very difficult business you
have to really work hard to get this
thing which cold luck which is based on
hard work anyway so I decided to move on
myself with my luck
like Einstein said life is like riding a
bicycle you must keep moving to keep
your balance so I wanted to do something
bigger and better
I needed a system that was both
therapeutic and preventive there is
nothing like that currently until I went
back to drawing board actually not the
drawing board the napkins because I
drink far too much coffee don’t do that
is really bad for your heart and yes I
came up with a new system where I wanted
I actually went ahead I took my own
blood I isolated this type of cells from
my blood label it with a new super power
system and we injected by in our bone
blood and what we were doing is that we
are keeping vessel integrity by making
sure that at early injury at early
injury all becomes well the vessels
don’t get damaged we don’t get rupture
and we don’t get broken hearts so this
whole business of many broken hearts
went very extreme because I had to get
leaders from all over the world a
scientific world in fact I was working
under the same lab as Israel e-juice
Palestinian Muslims and we are working
in harmony I also had to deploy military
experts and we really went all the way
to be together inside and outside the
lab so outside the lab I made an effort
to Reyn to join runners without
boundaries and human terian eighteens
unlikely missions I used to get shouted
a lot to the soldiers and that’s where
the Spitfire comes from that’s what they
call me and the reason was is because
without that helmet and that eye
protection
I could go blind any simple accident and
you go blind
now I’m going ask you something please
close your eyes but really close it you
have it open and now imagine how it will
be like to go blind you probably it’s
very unlikely that you will even be able
to find your handbags your heart must be
quite broken because that’s it you’re
not going to see it ever again
good good thing for the ladies it’s ok
if our clothes are not matching so now
imagine how could a soldier cope with
blindness someone that is not used to
being dependable or anyone someone that
always has missions now think about the
victims the manchester five days ago all
those civilians and many of them will
have to cope with blindness so that’s
the first time I came across blind
veterans you can be formally known as
st. Dunstan’s it started in 1915 by a
gentleman called Sir RT person and that
is 102 years ago and he vowed that he
was going be the blind man not a blind
man and he was going to make sure that
soldiers would live well work have fun
play games respect reversed effects of
blindness victory over blindness and you
may ask me what do hearts have to do
with eyes
well actually a lot eyes are highly
dependent well in good blood vessel
integrity just like the heart we need a
new blood
and that’s when I thought I also go in
to adapt this new system I created by
taking my own blood my own cells and put
it back to also reverse the effects of
blindness try to restore vision and like
sir asked you Pearson I want this to be
the treatment not a treatment I want us
to be able to prevent and treat disease
our methods are very promising
preclinical testing is astounding let me
tell you something else this whole
business of mending broken hearts is so
much more than physiological mended is
more I’m so much more than getting eyes
better and your heart better is also
about bringing people together sharing
information collaboration unity many of
my friends are also dogs juice also dogs
Muslims and we all really work well
together and this highlights the fact
that the future is highly
multidisciplinary and the future it is
right now and you are the future thank
you
[Music]
you
I must have been 14 maybe 15 years old
as I left school as always I know ask me
why I was making sure my tight worst my
tie was straight and I had no stains my
school uniform but the next thing I
remember hearing is grandad is in the
hospital he had a heart attack I will
never forget he was a Tuesday and on
every Tuesday I used to go running with
my grandfather this is my grandfather
that survived war he’s been in military
deployments and he survived extremism
but at that moment my grandfather was
being killed by his own heart I went
running straight away to the hospital in
eyes as I entered the hospital I saw him
sitting pale sick and worried in a
hospital bed next to him there was a
pile of papers and these papers had a
drawing of a heart and notes from his
surgeon the surgeon told me I’m going to
patch your grandfather’s heart tomorrow
morning but he said to patch it up not
mend it and I really wondered what was
going to happen to my grandfather and
actually at that moment I never really
paid much attention to hearts any hearts
even my own let me ask you a question
how many of you have been checking your
heart lately
raise your hands if you have checked
your heart well this is reflective that
we really don’t pay much attention to
our hearts in fact we very evil to our
hearts 95% of what all vascular disease
is preventable a few changes in our diet
our lifestyle increased heart an
increased exercise would really make us
better
in fact we are so Cruella Deville that
60% of us in this room will die for
cardiovascular disease or is
ramifications so I thought as a young
graduate in 2007 that I was going to do
something about it and early 2008 I
really despaired and I was looking out
of the window at University College
London labs and I saw the building in
front it was full of cement and building
works and I saw they were building the
London Center for nanotechnology so I
looked at it and I thought my stem cells
and I’m really not going to fix this
problem so I’d need to do something
about it why not use nanotechnology to
sort this problem and I really thought I
was sleep deprived going insane because
I was totally ignorant I just actually
learnt the word nanotechnology I had no
idea what that was so the next thing I
know a few months later a few too many
emails I set up a system by which I
would research and for distant areas
totally different areas of research
involving at least six different
universities in three different
countries and I tell you held two
conference calls and direct flights I
wanted to create a system to deliver
drugs in stem cells and get these to go
into your broken heart and really help
it to be mended the system would consist
of something brand new a totally novel
nanoparticle or none of thing I used to
call it and we would be able to deliver
delivered drugs with it so these cells
which we were putting in very hostile
situations with actually solved at the
time the major problems were one you
couldn’t really get stem cells to
survive in an impacted myocardium
because it was a really hostile area was
a bit like putting these stem cells into
a warzone and number two we really
didn’t have a system that could deliver
drugs and be trackable over time so I
thought let’s do this and in fact we
created a system by which it was all
biocompatible and ideal for human usage
obviously that was so 2030 right often
simple ideas involved very complex
experimentation
we went all the way from developing
physical instruments to surgical
apparatus
I used my initiative and I was
definitely not afraid can you we do it
yes we can’t and a few years later that
day had arrived the day which the data
show we could do it I really remember it
I was in Northville in Finland I spent
the whole winter in there and I had not
seen any natural daylight for a long
time in fact I was really really looking
forward to the good weather in London
ironic isn’t it
so just before I left and I boarded that
flight I got a call from a supervisor
saying well done I never thought you
would do it you’ve got so lucky this is
pretty much impossible and just a note
on luck I don’t believe in luck um luck
is a very very difficult business you
have to really work hard to get this
thing which cold luck which is based on
hard work anyway so I decided to move on
myself with my luck
like Einstein said life is like riding a
bicycle you must keep moving to keep
your balance so I wanted to do something
bigger and better
I needed a system that was both
therapeutic and preventive there is
nothing like that currently until I went
back to drawing board actually not the
drawing board the napkins because I
drink far too much coffee don’t do that
is really bad for your heart and yes I
came up with a new system where I wanted
I actually went ahead I took my own
blood I isolated this type of cells from
my blood label it with a new super power
system and we injected by in our bone
blood and what we were doing is that we
are keeping vessel integrity by making
sure that at early injury at early
injury all becomes well the vessels
don’t get damaged we don’t get rupture
and we don’t get broken hearts so this
whole business of many broken hearts
went very extreme because I had to get
leaders from all over the world a
scientific world in fact I was working
under the same lab as Israel e-juice
Palestinian Muslims and we are working
in harmony I also had to deploy military
experts and we really went all the way
to be together inside and outside the
lab so outside the lab I made an effort
to Reyn to join runners without
boundaries and human terian eighteens
unlikely missions I used to get shouted
a lot to the soldiers and that’s where
the Spitfire comes from that’s what they
call me and the reason was is because
without that helmet and that eye
protection
I could go blind any simple accident and
you go blind
now I’m going ask you something please
close your eyes but really close it you
have it open and now imagine how it will
be like to go blind you probably it’s
very unlikely that you will even be able
to find your handbags your heart must be
quite broken because that’s it you’re
not going to see it ever again
good good thing for the ladies it’s ok
if our clothes are not matching so now
imagine how could a soldier cope with
blindness someone that is not used to
being dependable or anyone someone that
always has missions now think about the
victims the manchester five days ago all
those civilians and many of them will
have to cope with blindness so that’s
the first time I came across blind
veterans you can be formally known as
st. Dunstan’s it started in 1915 by a
gentleman called Sir RT person and that
is 102 years ago and he vowed that he
was going be the blind man not a blind
man and he was going to make sure that
soldiers would live well work have fun
play games respect reversed effects of
blindness victory over blindness and you
may ask me what do hearts have to do
with eyes
well actually a lot eyes are highly
dependent well in good blood vessel
integrity just like the heart we need a
new blood
and that’s when I thought I also go in
to adapt this new system I created by
taking my own blood my own cells and put
it back to also reverse the effects of
blindness try to restore vision and like
sir asked you Pearson I want this to be
the treatment not a treatment I want us
to be able to prevent and treat disease
our methods are very promising
preclinical testing is astounding let me
tell you something else this whole
business of mending broken hearts is so
much more than physiological mended is
more I’m so much more than getting eyes
better and your heart better is also
about bringing people together sharing
information collaboration unity many of
my friends are also dogs juice also dogs
Muslims and we all really work well
together and this highlights the fact
that the future is highly
multidisciplinary and the future it is
right now and you are the future thank
you
[Music]
you
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