most diseases that we deal with a
patient comes in with diabetes and we
treat them every day for the rest of
their lives but there’s a billion people
out there that have diseases now like
diabetes where we can give them a new
pancreas or someone with renal failure
or someone that has a failed liver or a
heart that we can now replace that with
regenerative medicine so 10 years ago I
was in Washington at a meeting and was
introduced to regenerative medicine and
the notion that there’s a billion people
around the world that we can now when
they come into our office rather than
giving them a treatment every day for
the rest of their lives we can give them
a new organ so I know that sometimes
it’s hard to understand what this means
so I brought a new organ with me now I
wanted this to be a kidney or a liver or
a pancreas but when I went to my
anatomical model in my house the best
thing I could pull out that she or he
would let me have was this so this is
what so in the future when you come in
and you need an organ and you’re one of
the 1 billion people that need an organ
we’re gonna make you an organ so that’s
a story that I want to tell you today so
so when we define regenerative medicine
it’s a field where we can give you cells
tissues or organs and this field came
from tissue engineering which is a field
I’ve been involved in for 40 years where
I was growing nerves and other tissues
so the notion is that we can take
something like this rat and grow a human
ear on its back and that’s tissue
engineering where we bring all these
different people together and we can
take cells and create essentially any
part of the human body and the key to
that are stem cells and the major
advance 10 years ago was work by this
Japanese scientists who came up with the
notion that we can induce any cell in
your body and transform that cell into a
stem cell
so prior to this work we could take bone
marrow fat skin or a fetus and we can
harvest stem cells out of those tissues
now we can take these induced
pluripotential stem cells and
essentially take any cell in your body
and if we put it in the right medium we
can transform that cell into a stem cell
and take that stem cell and then grow
you your new stomach or a liver or
kidney or any organ you want even we
could consider growing you a new hand or
a face or skin after a burn so here to
understand these stem cells basically a
stem cell is an undifferentiated cell
it’s a cell that can become any cell it
can become your heart your nervous
system or in your mune system and once
you take this undifferentiated cell you
can move this cell and make it into an
adult cell that permanently becomes that
new cell to become part of this organ
but there’s more to making this organ
than just that because you need a
framework for this organ and you need
other bio factors to keep this organ
healthy so that when I give it to you it
basically replaces a missing part and
cures you of your disease so let’s put
all this together what are the
advantages of regeneration you can
create unlimited undamaged organ
availability you can prior Taurus prize
that patients in other words typically
we will try to take a patient for a
kidney transplant and pick someone young
and healthy like you in the audience but
if you’re a 90 years old you can no
longer be a candidate and you’d be
forced for instance to go under dialysis
and live only a few years so the whole
priority changes with gender
regenerative medicine in the sense that
the priority now becomes anybody with
the viable life can now become a
candidate because we can take their
cells and grow an organ and give them a
new life expectancy and rather than
organ transplantation where the
number of organs available are small and
you require immune suppression that all
goes away because now the organ
availability is unlimited and no longer
do we need to put you through immune
suppression because the cells that we
put back in you that make that organ or
your cells so let’s give you an example
of a friend of mine who’s a 90 year old
who we discover that he needs his aorta
replaced so that gets replaced in an
operation now possible 20 years ago it
wouldn’t have been turns out he has an
aortic valve that’s also failing and
that’s also replaced all done by going
through the groin and replacing it but
during these procedures there’s enough
dye that’s given to the patient that his
kidneys fail so now he’s going to be on
dialysis and lasts a few years and he’s
gonna then die unless we can give him a
new kidney so we have to sort of make
him a new kidney a custom kidney for him
now of course it won’t be a stomach and
to look a little bit more like this so
you all wrapped up and plastic ready to
go so how do i fabricate this for him in
a month so that’s the story so he wants
to come in we’re gonna study him and say
alright we’re gonna make him v be a new
kidney and ship it to him wherever he is
and then put it in so this is a story I
had a hard time finding one of these so
this does look a lot like an ace wrap
but imagine this in the futures of kid
so there’s a limit I spent a lot of time
in clinic getting everybody running
around trying to find what it looked
like a wrap kidney would look like but
so first you need to make a model of
that kidney and it doesn’t have to be an
exact shape model but it has to be a
model that models the blood vessels
where we’re going to attach to so a
company I helped start back in the early
90s is called m2s it’s located down here
by the airport in Lebanon and they can
model your body and here you see a
picture of kidneys being modeled and
then give you the exact model of where
the vessels are that you’re gonna
connect the kidney to because at some
point when we make this kidney we’re
gonna want to put it in the body and
then basically attach it snap it in
place to the vessels so here you can see
these 3d models of a liver kidneys and
even lung so any of these models been
made and this company has made about
300,000 or so models of the body to help
us when we treat patients and to vastly
meaning going up through the groin and
being able to either replace the aorta
or a or take valve but that modeling
capability using computers now allows us
to model and fabricate a new organ so
now what we need to do is go to this
patient harvest some cells and because
of that work done by that Japanese
scientist we can essentially harvest any
cell on the body and we can put that
cell through a process and induce it to
become a stem cell and then transform it
because when we make a kidney the kidney
may be made up of three or four
different types of cells and we have to
make a batch of each of these cells so
we can put them together to manufacture
a new kidney and really transform or do
this paradigm shift in medicine so
rather than treating him with dialysis
we’re gonna cure him with a new organ so
we’re gonna process this at a processing
plant now this could be Dartmouth
Hitchcock Medical Center it could be
this new facility the government’s
building down in Manchester with Dean
Kaman to manufacture organs that was
money given out last year or it could be
anywhere around the world there’s
centers like this being built in
grano in london to build these organs in
israel japan singapore and what we want
to do is create a scaffold or a
structure so not only do we have the
cells but we’re gonna have to somehow
print those cells into a structure a
scaffold or framework we have this
notion of 3d printing and everybody’s
heard about 3d printing but now instead
of 3d printing to make a box or some
kind of toy we’re gonna 3d print into a
framework and put cells in in the right
order of cells for vascular cells for
filtration all the different cells the
kidney has into the right framework to
build a kidney now we’ve been building
these one at a time in laboratories but
now the government’s funding us to
manufacture these in large numbers so
we’d use these fancy 3d printers and
essentially grow the organ for the
patient a specialized organ just to that
patient’s needs and then we need to
preserve it so here we see that’s
preserved when it’s all wrapped up ready
to go and it’s a little plastic so
you’re gonna have to build it somewhere
let’s say in Manchester and the patient
may be in Florida and then you’d put it
into this little container and ship it
by FedEx or DHS or whatever it would
arrive and then the surgeons down there
would put it in like kidney transplant
surgeons they would put it in but in
this case they order it and a few weeks
later or a month later it arrives and
they put it in place and to put it in
place they would use a robot so instead
of doing a big operation where they open
the patient up they would take one of
these and they would make a small
incision they would put it through the
incision and the robot would put its
arms in the patient and the robot would
then know the Anatomy precisely from
those 3d models we made this would have
little vessels coming off of it which
the ACE wrap doesn’t have
and those would then get plugged in so
the operation to put this in place might
take only 40 minutes
so taking a ninety-year-old we’ve
already given him in a new aorta we’ve
already given him a artic valve and now
we would plug in a new kidney or any
part that he needed to essentially cure
his disease but what about monitoring it
the FDA is and be very concerned about
whether this is going to fail or not so
when we build an Oregon versus a
transplanted organ we can embed micro
sensors all through the organ and these
micro sensors can send information out
to the FDA and the doctors so they’ll
know day by day minute by minute second
by second how this organs functioning
and the know if it’s failing to put the
patient back on dialysis or if the organ
needs to be removed they can remove it
and put a new one in and I put on up
there
submarines because if you don’t know all
that data that we worry about all the
time by companies at Google and
Microsoft they’re afraid of that data
being attacked so they’re actually
putting it on submarines in the ocean
right now which is pretty wild although
we don’t talk about it much so where did
this get us what’s the summary of this
for this friend of mine who’s 90 that
would have died without an organ like
this and but in his case he actually
recovered so in one month we could
fabricate an organ there would be
unlimited supply so anybody that needed
an organ would be able to get the organ
there’d be no immune suppression because
that organ to be made out of that
patient’s own cells we could put it in
using a robot so it’s a minimally
invasive operation that would only take
an hour or so so there’s less surgical
and medical risk so this will be a truly
a paradigm shift in our lifetime over
the next decade or so
the government just spent in the last 10
years two hundred million dollars
developing this technology for the
wounded soldier and now has given
another several hundred million dollars
based in Manchester as a ward
last year to start looking at how do we
go from one organ as I started with like
this to producing thousands of these so
that everybody in the audience can have
their organ made and ready to go so
wanted to give you a look in the area of
Medicine at a major paradigm shift
that’s happening right now around us
sponsored by the government and
happening in countries around the world
so we can look at how we go from
treating disease where you get
medication every day to essentially
curing disease where that’s it you come
in you get your organ and you’re better
thank you very much [Applause]
patient comes in with diabetes and we
treat them every day for the rest of
their lives but there’s a billion people
out there that have diseases now like
diabetes where we can give them a new
pancreas or someone with renal failure
or someone that has a failed liver or a
heart that we can now replace that with
regenerative medicine so 10 years ago I
was in Washington at a meeting and was
introduced to regenerative medicine and
the notion that there’s a billion people
around the world that we can now when
they come into our office rather than
giving them a treatment every day for
the rest of their lives we can give them
a new organ so I know that sometimes
it’s hard to understand what this means
so I brought a new organ with me now I
wanted this to be a kidney or a liver or
a pancreas but when I went to my
anatomical model in my house the best
thing I could pull out that she or he
would let me have was this so this is
what so in the future when you come in
and you need an organ and you’re one of
the 1 billion people that need an organ
we’re gonna make you an organ so that’s
a story that I want to tell you today so
so when we define regenerative medicine
it’s a field where we can give you cells
tissues or organs and this field came
from tissue engineering which is a field
I’ve been involved in for 40 years where
I was growing nerves and other tissues
so the notion is that we can take
something like this rat and grow a human
ear on its back and that’s tissue
engineering where we bring all these
different people together and we can
take cells and create essentially any
part of the human body and the key to
that are stem cells and the major
advance 10 years ago was work by this
Japanese scientists who came up with the
notion that we can induce any cell in
your body and transform that cell into a
stem cell
so prior to this work we could take bone
marrow fat skin or a fetus and we can
harvest stem cells out of those tissues
now we can take these induced
pluripotential stem cells and
essentially take any cell in your body
and if we put it in the right medium we
can transform that cell into a stem cell
and take that stem cell and then grow
you your new stomach or a liver or
kidney or any organ you want even we
could consider growing you a new hand or
a face or skin after a burn so here to
understand these stem cells basically a
stem cell is an undifferentiated cell
it’s a cell that can become any cell it
can become your heart your nervous
system or in your mune system and once
you take this undifferentiated cell you
can move this cell and make it into an
adult cell that permanently becomes that
new cell to become part of this organ
but there’s more to making this organ
than just that because you need a
framework for this organ and you need
other bio factors to keep this organ
healthy so that when I give it to you it
basically replaces a missing part and
cures you of your disease so let’s put
all this together what are the
advantages of regeneration you can
create unlimited undamaged organ
availability you can prior Taurus prize
that patients in other words typically
we will try to take a patient for a
kidney transplant and pick someone young
and healthy like you in the audience but
if you’re a 90 years old you can no
longer be a candidate and you’d be
forced for instance to go under dialysis
and live only a few years so the whole
priority changes with gender
regenerative medicine in the sense that
the priority now becomes anybody with
the viable life can now become a
candidate because we can take their
cells and grow an organ and give them a
new life expectancy and rather than
organ transplantation where the
number of organs available are small and
you require immune suppression that all
goes away because now the organ
availability is unlimited and no longer
do we need to put you through immune
suppression because the cells that we
put back in you that make that organ or
your cells so let’s give you an example
of a friend of mine who’s a 90 year old
who we discover that he needs his aorta
replaced so that gets replaced in an
operation now possible 20 years ago it
wouldn’t have been turns out he has an
aortic valve that’s also failing and
that’s also replaced all done by going
through the groin and replacing it but
during these procedures there’s enough
dye that’s given to the patient that his
kidneys fail so now he’s going to be on
dialysis and lasts a few years and he’s
gonna then die unless we can give him a
new kidney so we have to sort of make
him a new kidney a custom kidney for him
now of course it won’t be a stomach and
to look a little bit more like this so
you all wrapped up and plastic ready to
go so how do i fabricate this for him in
a month so that’s the story so he wants
to come in we’re gonna study him and say
alright we’re gonna make him v be a new
kidney and ship it to him wherever he is
and then put it in so this is a story I
had a hard time finding one of these so
this does look a lot like an ace wrap
but imagine this in the futures of kid
so there’s a limit I spent a lot of time
in clinic getting everybody running
around trying to find what it looked
like a wrap kidney would look like but
so first you need to make a model of
that kidney and it doesn’t have to be an
exact shape model but it has to be a
model that models the blood vessels
where we’re going to attach to so a
company I helped start back in the early
90s is called m2s it’s located down here
by the airport in Lebanon and they can
model your body and here you see a
picture of kidneys being modeled and
then give you the exact model of where
the vessels are that you’re gonna
connect the kidney to because at some
point when we make this kidney we’re
gonna want to put it in the body and
then basically attach it snap it in
place to the vessels so here you can see
these 3d models of a liver kidneys and
even lung so any of these models been
made and this company has made about
300,000 or so models of the body to help
us when we treat patients and to vastly
meaning going up through the groin and
being able to either replace the aorta
or a or take valve but that modeling
capability using computers now allows us
to model and fabricate a new organ so
now what we need to do is go to this
patient harvest some cells and because
of that work done by that Japanese
scientist we can essentially harvest any
cell on the body and we can put that
cell through a process and induce it to
become a stem cell and then transform it
because when we make a kidney the kidney
may be made up of three or four
different types of cells and we have to
make a batch of each of these cells so
we can put them together to manufacture
a new kidney and really transform or do
this paradigm shift in medicine so
rather than treating him with dialysis
we’re gonna cure him with a new organ so
we’re gonna process this at a processing
plant now this could be Dartmouth
Hitchcock Medical Center it could be
this new facility the government’s
building down in Manchester with Dean
Kaman to manufacture organs that was
money given out last year or it could be
anywhere around the world there’s
centers like this being built in
grano in london to build these organs in
israel japan singapore and what we want
to do is create a scaffold or a
structure so not only do we have the
cells but we’re gonna have to somehow
print those cells into a structure a
scaffold or framework we have this
notion of 3d printing and everybody’s
heard about 3d printing but now instead
of 3d printing to make a box or some
kind of toy we’re gonna 3d print into a
framework and put cells in in the right
order of cells for vascular cells for
filtration all the different cells the
kidney has into the right framework to
build a kidney now we’ve been building
these one at a time in laboratories but
now the government’s funding us to
manufacture these in large numbers so
we’d use these fancy 3d printers and
essentially grow the organ for the
patient a specialized organ just to that
patient’s needs and then we need to
preserve it so here we see that’s
preserved when it’s all wrapped up ready
to go and it’s a little plastic so
you’re gonna have to build it somewhere
let’s say in Manchester and the patient
may be in Florida and then you’d put it
into this little container and ship it
by FedEx or DHS or whatever it would
arrive and then the surgeons down there
would put it in like kidney transplant
surgeons they would put it in but in
this case they order it and a few weeks
later or a month later it arrives and
they put it in place and to put it in
place they would use a robot so instead
of doing a big operation where they open
the patient up they would take one of
these and they would make a small
incision they would put it through the
incision and the robot would put its
arms in the patient and the robot would
then know the Anatomy precisely from
those 3d models we made this would have
little vessels coming off of it which
the ACE wrap doesn’t have
and those would then get plugged in so
the operation to put this in place might
take only 40 minutes
so taking a ninety-year-old we’ve
already given him in a new aorta we’ve
already given him a artic valve and now
we would plug in a new kidney or any
part that he needed to essentially cure
his disease but what about monitoring it
the FDA is and be very concerned about
whether this is going to fail or not so
when we build an Oregon versus a
transplanted organ we can embed micro
sensors all through the organ and these
micro sensors can send information out
to the FDA and the doctors so they’ll
know day by day minute by minute second
by second how this organs functioning
and the know if it’s failing to put the
patient back on dialysis or if the organ
needs to be removed they can remove it
and put a new one in and I put on up
there
submarines because if you don’t know all
that data that we worry about all the
time by companies at Google and
Microsoft they’re afraid of that data
being attacked so they’re actually
putting it on submarines in the ocean
right now which is pretty wild although
we don’t talk about it much so where did
this get us what’s the summary of this
for this friend of mine who’s 90 that
would have died without an organ like
this and but in his case he actually
recovered so in one month we could
fabricate an organ there would be
unlimited supply so anybody that needed
an organ would be able to get the organ
there’d be no immune suppression because
that organ to be made out of that
patient’s own cells we could put it in
using a robot so it’s a minimally
invasive operation that would only take
an hour or so so there’s less surgical
and medical risk so this will be a truly
a paradigm shift in our lifetime over
the next decade or so
the government just spent in the last 10
years two hundred million dollars
developing this technology for the
wounded soldier and now has given
another several hundred million dollars
based in Manchester as a ward
last year to start looking at how do we
go from one organ as I started with like
this to producing thousands of these so
that everybody in the audience can have
their organ made and ready to go so
wanted to give you a look in the area of
Medicine at a major paradigm shift
that’s happening right now around us
sponsored by the government and
happening in countries around the world
so we can look at how we go from
treating disease where you get
medication every day to essentially
curing disease where that’s it you come
in you get your organ and you’re better
thank you very much [Applause]
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