[Music]
[Applause]
outside aficionados scrabble
I checked it’s sixty 1
fifteen points in triple word score
how many of you thought this morning
in cancer immuno thousand names
no name to name but a e10 louis
michel family it does not work
sorry yen has a ball that’s me
because the cancer is immune
one important thing is one thing
serious
Besides talking to you I
Professor donned my coat
immunology at the faculty of
Medicine Head of Immunology
chu of the reindeer and Director
Research Unit INSERM U 1236
microenvironment differentiation
cellular immunology and cancer yes
little wink all women
wear blues are not
nurse or laborantine
in cancer immuno ago
Immunology Study System
immune
the system that you francs against
viruses bacteria that sticks
allergies and incidentally that you
lets make babies
no gentlemen in the front row I speak
no the first half hour
Finally, the first three minutes
sometimes a year I speak of you ladies
nine months after those where less
you be reproduced with your
twin brother that I wish you
not you tolerate a fetus which is a
alien totally incompatible with you
an immunologically at least
So immunology and immuno
Cancer there are also cancer
yes because today I will
about cancer a disease that you
then I could respect all you
talk about the risk factors for cancer
remember that tobacco is the
leading cause of cancer that is what
true or while pesticides Odos
totally for farmers
increases the risk of certain cancers
This is also true
bright interior salads and therefore
that cancer is a real issue
public health but not he will act
not here today a vision
societal cancer I might as
explain the differences
Genetic between the
different types of cancers or at
within the same type of cancer among
different patients or for
same patient between the primary tumor
and its metastases
but no it will not a
course on cancer genetics not
if I’m here today is
to talk about the very network
entangled interaction which
develops between firstly the cells
tumor and other cells
In particular normal immune
is this dialogue promotes growth
tumor and knows what form
called tumor nests
yes I’m here today is
well for you to talk immuno
Cancer unlucky but before
this short little background on
what we might call the mode
Science and science as fact
Besides fashion is so much more
coat the theory that our
immune system protects us
against cancer
also called theory of immuno
Surveillance actually early
20th century
it is based on the idea that a cell
cancer is recognized by the system
immune as different from
normal type control cells
identity and show me your papers
it will be destroyed by this
immune system but the failure in
the 70 80 strategies
vaccination anti cancer even
we were able to recruit within
tumor
many of these policemen
immune system but they
were sometimes proved completely
incompetence led to the abandonment
complete disregard for these
approaches of both a point of view
scientific and financial goodbye immuno
Cancer therapies bright
Targeted effect just when
held the incredible progress
high throughput sequencing that allows
read in record time all
the genetic code of a cell and
even knowing all that it produces
at the rate of 1
I stop you two later
facets is done in several hours
not so fast that there is
in the experts that a guy waving
staggers turned his super mega
software or in 12 seconds appears the
suspect’s photo that is none other than
false gardener upstream of the victim
the researchers then tried
identifying among these alterations
Genetic which really were
responsible for cancer or because
they promoted the proliferation
the growth of tumor cells
either because they were blocking their death
in parallel of course we have sought
to target these genetic alterations
by small chemical molecules
it is the development of targeted therapies and
ultimately it is only very
recently that super bright
synology those cancers and super
brilliant geneticist cancers is
expressed and we group them tomorrow
ordain the common salvation indeed it
came to realize a
Obviously most of tumor cells and
abnormal from a genetic point of view
more likely it is to be seen and
recognized by the immune system and
potentially destroyed
it was time to work together
and more during this period
inconsistencies found that the niche
tumor immune system
infiltrating tumor consists
a crude good association and
mobsters good the good guys we want it
immune cells are anti
tumor and in particular that
called killer lymphocytes or
cytotoxic
to be effective they must
are many
it’s like in a democracy must
be many to hear his
voice if you see what I mean
but it must also be able to
specifically recognize tumor
suspect this is the first factor
limiting in many cases including
when the tumor has many
genetic alteration
these parameters are met and
yet it is not destroyed
why because his kind are
as often in real life some
how to say what a nice nice
little
soft knee and that’s because
that the cancer cell expressed his
surface to escape
Brake molecules that blocks it
must therefore re awaken these
nice policemen
and why it has a new
class of drugs that are
antibodies raising his brakes so as
the land of candy
there are nice and there are
evil and the wicked are
effective super super twisted they are
true psychopaths
we distinguish two categories
the first will directly stimulate
the second tumor cells are
promote the construction
the organization of the niche for example
they can promote the formation of
new blood vessels or they
will actively block the
nice gendarmes making them all
soft as we have seen previously
found in this category by
such as regulatory T cells
and today we must have
expect the strategy to
destroy
Finally, as in any good western ago
mobsters potentially guys
nice but actually much sneaky and
can do evil is found there by
eg associated macrophages
tumors so they can eat them
cells of the month is ca c is good but
they can also produce factors
pro tumor and this is clearly
less good
then the objective is of the
reeducate bring them back to the right
path
Wholesale transform the wicked
nice in very nice unit
inserm
I lead him in 1236 well we
is interested in these types of
cells how they
dialogue between themselves which it operates
the tumor with which they organize
Ecosystems in a type
particular tumor called
lymphoma tumor nodes
which is an excellent niche model
Tumor full of good raw and
mobsters and it has been demonstrated
recently that alterations
the most common genetic
prevents tumor cells
producing an antitumor factor that
calls hvm the same age and loss
powerfully pro tumor because it
will both directly activated
cancer cells but also
promote great evil that will
boost and promote tumors
Construction of the niche too balèze
in these conditions was bluntly pointed
Call raids cytotoxic cells
super efficient and super specific
the tumor while the raid a judge you
remember this is the team that looks like
maybe Brad Pitt or George
clooney
but in fact we do not know anything because
they are always hidden what
so we made a little similar in
cells its toxic water
was introduced surreptitiously
molecule in Geneva was reintroduced
all in diseased mice and
killer cells have both
destroy the tumor and relegating the
hvm inhibit the super villains too
strong so why this afternoon I
‘m here to talk immuno
Cancer while most
of you fortunately you
never develop lymphoma
while for all of you
you were you ever wondered
question of the tumor nests those
well you did is so wrong all
First maybe getting a
slightly less silly finally what I think
already be a laudable goal
no no no in fact it is not that but
the idea is that while
Genetic alterations are
specific to each cancer
these mechanisms of interaction between
cancer cells and their niches
are common to all cancers and
time knowledge born of
new therapeutic strategies
which are potentially effective in
all cancers
the prospects are huge
but the first exciting results
extremely high cost of these
therapeutic will impact all
our health system
so actually yes today I am
also here to talk about an issue
Societal that of knowing what you
Want to make your health system
what you want to do other
research systems
this is an issue that does not concern
a 10 cent or thousand people here but
for all of us thank you
[Applause]
[Applause]
outside aficionados scrabble
I checked it’s sixty 1
fifteen points in triple word score
how many of you thought this morning
in cancer immuno thousand names
no name to name but a e10 louis
michel family it does not work
sorry yen has a ball that’s me
because the cancer is immune
one important thing is one thing
serious
Besides talking to you I
Professor donned my coat
immunology at the faculty of
Medicine Head of Immunology
chu of the reindeer and Director
Research Unit INSERM U 1236
microenvironment differentiation
cellular immunology and cancer yes
little wink all women
wear blues are not
nurse or laborantine
in cancer immuno ago
Immunology Study System
immune
the system that you francs against
viruses bacteria that sticks
allergies and incidentally that you
lets make babies
no gentlemen in the front row I speak
no the first half hour
Finally, the first three minutes
sometimes a year I speak of you ladies
nine months after those where less
you be reproduced with your
twin brother that I wish you
not you tolerate a fetus which is a
alien totally incompatible with you
an immunologically at least
So immunology and immuno
Cancer there are also cancer
yes because today I will
about cancer a disease that you
then I could respect all you
talk about the risk factors for cancer
remember that tobacco is the
leading cause of cancer that is what
true or while pesticides Odos
totally for farmers
increases the risk of certain cancers
This is also true
bright interior salads and therefore
that cancer is a real issue
public health but not he will act
not here today a vision
societal cancer I might as
explain the differences
Genetic between the
different types of cancers or at
within the same type of cancer among
different patients or for
same patient between the primary tumor
and its metastases
but no it will not a
course on cancer genetics not
if I’m here today is
to talk about the very network
entangled interaction which
develops between firstly the cells
tumor and other cells
In particular normal immune
is this dialogue promotes growth
tumor and knows what form
called tumor nests
yes I’m here today is
well for you to talk immuno
Cancer unlucky but before
this short little background on
what we might call the mode
Science and science as fact
Besides fashion is so much more
coat the theory that our
immune system protects us
against cancer
also called theory of immuno
Surveillance actually early
20th century
it is based on the idea that a cell
cancer is recognized by the system
immune as different from
normal type control cells
identity and show me your papers
it will be destroyed by this
immune system but the failure in
the 70 80 strategies
vaccination anti cancer even
we were able to recruit within
tumor
many of these policemen
immune system but they
were sometimes proved completely
incompetence led to the abandonment
complete disregard for these
approaches of both a point of view
scientific and financial goodbye immuno
Cancer therapies bright
Targeted effect just when
held the incredible progress
high throughput sequencing that allows
read in record time all
the genetic code of a cell and
even knowing all that it produces
at the rate of 1
I stop you two later
facets is done in several hours
not so fast that there is
in the experts that a guy waving
staggers turned his super mega
software or in 12 seconds appears the
suspect’s photo that is none other than
false gardener upstream of the victim
the researchers then tried
identifying among these alterations
Genetic which really were
responsible for cancer or because
they promoted the proliferation
the growth of tumor cells
either because they were blocking their death
in parallel of course we have sought
to target these genetic alterations
by small chemical molecules
it is the development of targeted therapies and
ultimately it is only very
recently that super bright
synology those cancers and super
brilliant geneticist cancers is
expressed and we group them tomorrow
ordain the common salvation indeed it
came to realize a
Obviously most of tumor cells and
abnormal from a genetic point of view
more likely it is to be seen and
recognized by the immune system and
potentially destroyed
it was time to work together
and more during this period
inconsistencies found that the niche
tumor immune system
infiltrating tumor consists
a crude good association and
mobsters good the good guys we want it
immune cells are anti
tumor and in particular that
called killer lymphocytes or
cytotoxic
to be effective they must
are many
it’s like in a democracy must
be many to hear his
voice if you see what I mean
but it must also be able to
specifically recognize tumor
suspect this is the first factor
limiting in many cases including
when the tumor has many
genetic alteration
these parameters are met and
yet it is not destroyed
why because his kind are
as often in real life some
how to say what a nice nice
little
soft knee and that’s because
that the cancer cell expressed his
surface to escape
Brake molecules that blocks it
must therefore re awaken these
nice policemen
and why it has a new
class of drugs that are
antibodies raising his brakes so as
the land of candy
there are nice and there are
evil and the wicked are
effective super super twisted they are
true psychopaths
we distinguish two categories
the first will directly stimulate
the second tumor cells are
promote the construction
the organization of the niche for example
they can promote the formation of
new blood vessels or they
will actively block the
nice gendarmes making them all
soft as we have seen previously
found in this category by
such as regulatory T cells
and today we must have
expect the strategy to
destroy
Finally, as in any good western ago
mobsters potentially guys
nice but actually much sneaky and
can do evil is found there by
eg associated macrophages
tumors so they can eat them
cells of the month is ca c is good but
they can also produce factors
pro tumor and this is clearly
less good
then the objective is of the
reeducate bring them back to the right
path
Wholesale transform the wicked
nice in very nice unit
inserm
I lead him in 1236 well we
is interested in these types of
cells how they
dialogue between themselves which it operates
the tumor with which they organize
Ecosystems in a type
particular tumor called
lymphoma tumor nodes
which is an excellent niche model
Tumor full of good raw and
mobsters and it has been demonstrated
recently that alterations
the most common genetic
prevents tumor cells
producing an antitumor factor that
calls hvm the same age and loss
powerfully pro tumor because it
will both directly activated
cancer cells but also
promote great evil that will
boost and promote tumors
Construction of the niche too balèze
in these conditions was bluntly pointed
Call raids cytotoxic cells
super efficient and super specific
the tumor while the raid a judge you
remember this is the team that looks like
maybe Brad Pitt or George
clooney
but in fact we do not know anything because
they are always hidden what
so we made a little similar in
cells its toxic water
was introduced surreptitiously
molecule in Geneva was reintroduced
all in diseased mice and
killer cells have both
destroy the tumor and relegating the
hvm inhibit the super villains too
strong so why this afternoon I
‘m here to talk immuno
Cancer while most
of you fortunately you
never develop lymphoma
while for all of you
you were you ever wondered
question of the tumor nests those
well you did is so wrong all
First maybe getting a
slightly less silly finally what I think
already be a laudable goal
no no no in fact it is not that but
the idea is that while
Genetic alterations are
specific to each cancer
these mechanisms of interaction between
cancer cells and their niches
are common to all cancers and
time knowledge born of
new therapeutic strategies
which are potentially effective in
all cancers
the prospects are huge
but the first exciting results
extremely high cost of these
therapeutic will impact all
our health system
so actually yes today I am
also here to talk about an issue
Societal that of knowing what you
Want to make your health system
what you want to do other
research systems
this is an issue that does not concern
a 10 cent or thousand people here but
for all of us thank you
[Applause]
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