[music]
thank you audience thank you
Today you are here with us in Astana
each of us wondered about his
the origin of who our ancestors were
where do they come from, what are we
some of us inherited from them
have saved clues to these questions in
family pedigrees
genealogical memory has a temporary
boundaries is how many of your tracks remember
for example, you have a tradition for Kazakhs
account
memory of seven ancestors on the paternal line
the pedigree of different peoples
is presented in different ways but unites them
one is often one part of genealogy
forget the other part enveloped
contradictory legends
in this situation, our tips
become traps but today
thanks to modern methods of genetics
you can learn about your background even
if you absolutely do not know your
genealogy and, moreover, to find their own
relatives around the world I’m a geneticist
I study gene pool of Kazakhstan including
for five years
I make up a genetic pedigree
Kazakhs studying the history of formation
our population ethnogenesis process
complex for its study is applied
interdisciplinary in nature and
knowledge of archeology and
anthropology and the history of linguistics from
taxes and for the last two decades
knowledge of genetics is actively involved
The study of origin is not only
A glimpse into the past in history is also
a look into the future of medicine
criminology education
The future which can become more
safe for your children
The future in which the dream of the Olympic
medals or salvation from hereditary
disease will only be a matter of choice
how about this briefly I
today I’ll tell you and try
explain why each of us
it is necessary to digitize your genome
probably many of you are familiar with this
the concept of a gene
well, or at least heard of him in
genome is hereditary
information that makes us so
what we are a physical genome
the DNA molecules are presented
the digital profile of the genome can be
in the form of written text
only four letters abcd it
nucleotides of a molecule
genome in different organisms
differs so in 2003 with efforts
scientists was first sequenced that is
read or in other words digitized
the human genome and all the following
years we are engaged in the interpretation of genetics
deciphering the meaning of this text
to understand how the hereditary
information the human genome is the text
three billion characters from
four letters it is possible to imagine that
nature shares this text with
Foreword and 23 eyes
mitochondrial DNA is inherited only
by maternal line
23 chapters are our 23 pairs of chromosomes so
the genome of each of us this book
book that must be read and
understand but how much our books
the comparison differs from each other
human genomes show that
99.9 percent are identical and only
one tenth of a percent makes us
unique unlike each other
each newborn child receives 70
of new
differences in the genome of which was not
parents and so on throughout
history of the human species, we
accumulated
changes in genetic variants in our
genome and each option has its own
an amazing story when
how did she come about
inherited the most raster systems
spread around the world more
Each option has its own
predestination
one way or another affecting our destiny
my research was devoted to one of the
chapters in this book
y-chromosome, it is only in men and in
women instead of y chromosome 2 x chromosome
The peculiarity of the y-chromosome is in
that it is inherited from the father
lines and all the changes that have occurred in it
the history of the genome is the easiest
track both during and
space
I began to study the y-chromosome 5 years ago
back when on the map of the study of all
of peoples of our region
this study was a blank spot
began in the framework of international
project of the geography of geography is financed by our
but a geographer besides the Kazakhs
is one of the largest
tribal group of the Eurasian steppe
which has been preserved by our tradition in the seam
and many foreign researchers
were interested in studying as well
affiliation
inherits in the same way as y
chromosome from father to son
that is, our tradition was a model
for the study and comparison of concepts
social and biological genus
well and of course our region located on the
historical migration between
west and east is an important
puzzle in the mosaic of the gene pool of mankind
gene pool of the peoples of Central Asia
study to the end therefore remains
the actual task for us I read
certain parts of y-chromosomes in almost
2000 and Kazakhs from different regions of our
countries with different genealogy and me with my
colleagues managed to learn the basic
moments of its history which options
meet and we have with whom and when they
could be introduced into our gene pool in
our historical record
for example, there is a variant of the y-chromosome
which we found most often in
representatives of the genus organ this option
raises them to one common biological
ancestor of which according to molecular
hours lived in the 14th century juxtaposition
historical data with genetics
indicate what could be
Ordynian salad and the world of kara hodge
diplomat and organizer of coinage at
yard taffeta mouse khan and such
biological ancestors are many
of Kazakh genera
information on them can be found in
historical information in our and staff
and in fact they are
fathers-founders of our people and
Each father-founder has his own
long amazing history of the y-chromosome
which begins in Africa 250 years
thousands of years ago and today someone’s
y-chromosome
to bear on the Sibiri of Mongolia with the peoples
someone’s with the peoples of central Asia
someone with the peoples of the front asia someone’s
Native Americans and in fact
a related link can be found
with the entire world of the y-chromosome, although
is one of the small chapters of our
genome it contains a whole story
our great-grandfathers
just like in the mitochondrial DNA
written the whole story of our grandmothers in
other chapters of our genome recorded more
more information about our multifaceted
history until we are
relatives with Neanderthals and
my view is the second wind for
history when new knowledge gained from
using genetics at open
Unknown pages of history supplement
a picture of ethnogeny as a whole the gene pool
Kazakhs as a single whole and indivisible
our preliminary data
finally formed in the 13th and 14th centuries and
Today
Kazakh are out as if it’s enough
homogeneous, that is, the Kazakhs are very similar
at each other genetically despite
that we are separated over a vast territory
and preserve the memory of the generic structure
But more about this in more detail about
genetically and pedigree of Kazakhs
recent research results
ancient dnk culture as well as
Scythians about the genetic heritage of the empire
Mongols and Turks as the role of tribal
structure of formation of architectonics
gene pool
Perhaps I will tell you in separate
special my lectures dedicated
genetic history of our
gene pool
and today only stressed the main thing
long known fact that the essence of
genetic relationship is
that we are here all sitting different it is a
are relatives of just someone
closer
and someone further please remember about
This is always the individuality of each
only unites us by studying
origin of genetics we create bio
Population banks form genomic
databases, these databases are not only
fundamental scientific value but also
practical based on this information
we are on a biological model
unknown person can determine
where could his ancestors have come from?
genetic lines it refers to where
seek his close relatives
development and implementation of such
criminology
in practice the countries of Europe and the USA
allowed three or more times to accelerate
I will not reveal the crimes
go far after the example of science
fatal directors of my thesis
helped uncover
where could there be a terrorist who blew up
yourself at the Domodedovo airport in 2011
purposeful reinforced quickly
search operations in the region where he
indicated on the map allowed investigative
committee to quickly discover the network
the organizers of the terrorist act thus
prevent subsequent explosions which
planned and this result has become
possible only thanks to the accumulated
scientific basis for the variability of the y-chromosome
that the peoples of Northern Eurasia
was formed over 20 years of Moscow
scientific school of the geography gene therefore
digitizing the genomes of the whole population or
at least creation of such reference bases
data is fundamental to the
our national security
both in local and global
perspective
my human genetics lab
created this year under the national
center, biotechnology is setting itself
such tasks and are ready to solve for
state in the national
Security also includes
health care
genomic bases are necessary for medicine
future as I told everyone
genetic variant has its own
predestination of any of them
increase the risk of developing a
certain diseases
they are on the contrary attached to some
competitive advantage for example if
you have certain mutations in the gene and
tumor suppressors
such as for example version 1 or birds 2
then there is a risk of developing a cancer tumor
mammary gland
therefore all over the world are actively introduced
modern diagnostic methods
molecular mutations associated with
diseases
it is worth noting the fact that
treatment depends entirely on our
genetics
genomic variants of our make us
differently susceptible to different doses
medicines
A vivid example can be warfarin of his
appoint people with problems
cardiovascular diseases
propensity to thrombosis when in
blood clot appear clots
prevent disturbing the blood circulation and so
if you have certain mutations in
gene and the responsible coding enzyme
cytochrome p450 or vitamin it to you
it is worth thinking about
adjust
dose of the drug used to
improve the efficiency of the treatment and
digital genomes
healthy and sick people we are genetics
we study the genetic basis of diseases
which further allow in advance
learn about the dangers to our
health about genetic Georgia
moreover , today it is time
when you can treat them with
gene therapy, and in my view it
there is future health care second
breathing for you is friable for
health way to medicine for the future
genomic and personalized history
criminology
health education and even sports
importance of examples of genetic
research can be brought endlessly
but also for many of you can
seem endless far these topics
only sphere of interests
scientists and experts therefore
give another example that can
be a motivation for you to follow
news from the world of genetics in the last
time in our society is gaining
popularity is such a way of life as
vegetarianism
but as far as it is suitable for us, scientists
approach to the answer to this question in
under the international project, thousands
genomes
from different parts of the world were compared
genomic variants of traditional meat-eaters
and vegan so here if you do not have
certain mutations in the fat gene from 2
such as those responsible for digestion
is associated with unsaturated fatty
with omega-3 omega-6 acids
then giving up meat and fish increases the risk
development of colon cancer therefore
Kazakhs do not refuse so sharply from
beshbarmaki
[applause]
Thus, the digitization of genomes is
key in the knowledge of the nature of our living
origin and creation
opportunities to improve the quality and
our understanding of this
thesis
grows every day and today
Brittany digitize the genomes of 100 thousand
of their citizens, France is 235 thousand
at least one point four billion
South Korea has a project
digitize the genome of each
Korean on earth
Iceland almost studied all its
population and a list of countries that
set themselves such a national
The task is increasing every year with our
neighbors started to take up the
project of thousands of Russian genomes
technology digitization is improved
every year and its price falls exactly like that
we have such a long-term
strategic national tasks
set
but today we put it together with you
in front of you and tomorrow will put our
government of us only 18 million
Kazakhstan we live on a vast rich
territory resources of the territory we have
As the nation has grandiose plans and
hopes for our future and
each of us seeks to do so
I am sure that we are our research in
perspective
we will close this white spot and our
The state will allow and create
possibilities for digitizing the genome of each
our citizen so that everyone can
get the key to her to read your
genome of its origin so that each
could learn his hereditary deposit
opportunities to open their talents to
each of us could bring our
dream or change it without changing yourself
Thank you for attention
with you was a geneticist maksat
[applause]
[music]
[music]
thank you audience thank you
Today you are here with us in Astana
each of us wondered about his
the origin of who our ancestors were
where do they come from, what are we
some of us inherited from them
have saved clues to these questions in
family pedigrees
genealogical memory has a temporary
boundaries is how many of your tracks remember
for example, you have a tradition for Kazakhs
account
memory of seven ancestors on the paternal line
the pedigree of different peoples
is presented in different ways but unites them
one is often one part of genealogy
forget the other part enveloped
contradictory legends
in this situation, our tips
become traps but today
thanks to modern methods of genetics
you can learn about your background even
if you absolutely do not know your
genealogy and, moreover, to find their own
relatives around the world I’m a geneticist
I study gene pool of Kazakhstan including
for five years
I make up a genetic pedigree
Kazakhs studying the history of formation
our population ethnogenesis process
complex for its study is applied
interdisciplinary in nature and
knowledge of archeology and
anthropology and the history of linguistics from
taxes and for the last two decades
knowledge of genetics is actively involved
The study of origin is not only
A glimpse into the past in history is also
a look into the future of medicine
criminology education
The future which can become more
safe for your children
The future in which the dream of the Olympic
medals or salvation from hereditary
disease will only be a matter of choice
how about this briefly I
today I’ll tell you and try
explain why each of us
it is necessary to digitize your genome
probably many of you are familiar with this
the concept of a gene
well, or at least heard of him in
genome is hereditary
information that makes us so
what we are a physical genome
the DNA molecules are presented
the digital profile of the genome can be
in the form of written text
only four letters abcd it
nucleotides of a molecule
genome in different organisms
differs so in 2003 with efforts
scientists was first sequenced that is
read or in other words digitized
the human genome and all the following
years we are engaged in the interpretation of genetics
deciphering the meaning of this text
to understand how the hereditary
information the human genome is the text
three billion characters from
four letters it is possible to imagine that
nature shares this text with
Foreword and 23 eyes
mitochondrial DNA is inherited only
by maternal line
23 chapters are our 23 pairs of chromosomes so
the genome of each of us this book
book that must be read and
understand but how much our books
the comparison differs from each other
human genomes show that
99.9 percent are identical and only
one tenth of a percent makes us
unique unlike each other
each newborn child receives 70
of new
differences in the genome of which was not
parents and so on throughout
history of the human species, we
accumulated
changes in genetic variants in our
genome and each option has its own
an amazing story when
how did she come about
inherited the most raster systems
spread around the world more
Each option has its own
predestination
one way or another affecting our destiny
my research was devoted to one of the
chapters in this book
y-chromosome, it is only in men and in
women instead of y chromosome 2 x chromosome
The peculiarity of the y-chromosome is in
that it is inherited from the father
lines and all the changes that have occurred in it
the history of the genome is the easiest
track both during and
space
I began to study the y-chromosome 5 years ago
back when on the map of the study of all
of peoples of our region
this study was a blank spot
began in the framework of international
project of the geography of geography is financed by our
but a geographer besides the Kazakhs
is one of the largest
tribal group of the Eurasian steppe
which has been preserved by our tradition in the seam
and many foreign researchers
were interested in studying as well
affiliation
inherits in the same way as y
chromosome from father to son
that is, our tradition was a model
for the study and comparison of concepts
social and biological genus
well and of course our region located on the
historical migration between
west and east is an important
puzzle in the mosaic of the gene pool of mankind
gene pool of the peoples of Central Asia
study to the end therefore remains
the actual task for us I read
certain parts of y-chromosomes in almost
2000 and Kazakhs from different regions of our
countries with different genealogy and me with my
colleagues managed to learn the basic
moments of its history which options
meet and we have with whom and when they
could be introduced into our gene pool in
our historical record
for example, there is a variant of the y-chromosome
which we found most often in
representatives of the genus organ this option
raises them to one common biological
ancestor of which according to molecular
hours lived in the 14th century juxtaposition
historical data with genetics
indicate what could be
Ordynian salad and the world of kara hodge
diplomat and organizer of coinage at
yard taffeta mouse khan and such
biological ancestors are many
of Kazakh genera
information on them can be found in
historical information in our and staff
and in fact they are
fathers-founders of our people and
Each father-founder has his own
long amazing history of the y-chromosome
which begins in Africa 250 years
thousands of years ago and today someone’s
y-chromosome
to bear on the Sibiri of Mongolia with the peoples
someone’s with the peoples of central Asia
someone with the peoples of the front asia someone’s
Native Americans and in fact
a related link can be found
with the entire world of the y-chromosome, although
is one of the small chapters of our
genome it contains a whole story
our great-grandfathers
just like in the mitochondrial DNA
written the whole story of our grandmothers in
other chapters of our genome recorded more
more information about our multifaceted
history until we are
relatives with Neanderthals and
my view is the second wind for
history when new knowledge gained from
using genetics at open
Unknown pages of history supplement
a picture of ethnogeny as a whole the gene pool
Kazakhs as a single whole and indivisible
our preliminary data
finally formed in the 13th and 14th centuries and
Today
Kazakh are out as if it’s enough
homogeneous, that is, the Kazakhs are very similar
at each other genetically despite
that we are separated over a vast territory
and preserve the memory of the generic structure
But more about this in more detail about
genetically and pedigree of Kazakhs
recent research results
ancient dnk culture as well as
Scythians about the genetic heritage of the empire
Mongols and Turks as the role of tribal
structure of formation of architectonics
gene pool
Perhaps I will tell you in separate
special my lectures dedicated
genetic history of our
gene pool
and today only stressed the main thing
long known fact that the essence of
genetic relationship is
that we are here all sitting different it is a
are relatives of just someone
closer
and someone further please remember about
This is always the individuality of each
only unites us by studying
origin of genetics we create bio
Population banks form genomic
databases, these databases are not only
fundamental scientific value but also
practical based on this information
we are on a biological model
unknown person can determine
where could his ancestors have come from?
genetic lines it refers to where
seek his close relatives
development and implementation of such
criminology
in practice the countries of Europe and the USA
allowed three or more times to accelerate
I will not reveal the crimes
go far after the example of science
fatal directors of my thesis
helped uncover
where could there be a terrorist who blew up
yourself at the Domodedovo airport in 2011
purposeful reinforced quickly
search operations in the region where he
indicated on the map allowed investigative
committee to quickly discover the network
the organizers of the terrorist act thus
prevent subsequent explosions which
planned and this result has become
possible only thanks to the accumulated
scientific basis for the variability of the y-chromosome
that the peoples of Northern Eurasia
was formed over 20 years of Moscow
scientific school of the geography gene therefore
digitizing the genomes of the whole population or
at least creation of such reference bases
data is fundamental to the
our national security
both in local and global
perspective
my human genetics lab
created this year under the national
center, biotechnology is setting itself
such tasks and are ready to solve for
state in the national
Security also includes
health care
genomic bases are necessary for medicine
future as I told everyone
genetic variant has its own
predestination of any of them
increase the risk of developing a
certain diseases
they are on the contrary attached to some
competitive advantage for example if
you have certain mutations in the gene and
tumor suppressors
such as for example version 1 or birds 2
then there is a risk of developing a cancer tumor
mammary gland
therefore all over the world are actively introduced
modern diagnostic methods
molecular mutations associated with
diseases
it is worth noting the fact that
treatment depends entirely on our
genetics
genomic variants of our make us
differently susceptible to different doses
medicines
A vivid example can be warfarin of his
appoint people with problems
cardiovascular diseases
propensity to thrombosis when in
blood clot appear clots
prevent disturbing the blood circulation and so
if you have certain mutations in
gene and the responsible coding enzyme
cytochrome p450 or vitamin it to you
it is worth thinking about
adjust
dose of the drug used to
improve the efficiency of the treatment and
digital genomes
healthy and sick people we are genetics
we study the genetic basis of diseases
which further allow in advance
learn about the dangers to our
health about genetic Georgia
moreover , today it is time
when you can treat them with
gene therapy, and in my view it
there is future health care second
breathing for you is friable for
health way to medicine for the future
genomic and personalized history
criminology
health education and even sports
importance of examples of genetic
research can be brought endlessly
but also for many of you can
seem endless far these topics
only sphere of interests
scientists and experts therefore
give another example that can
be a motivation for you to follow
news from the world of genetics in the last
time in our society is gaining
popularity is such a way of life as
vegetarianism
but as far as it is suitable for us, scientists
approach to the answer to this question in
under the international project, thousands
genomes
from different parts of the world were compared
genomic variants of traditional meat-eaters
and vegan so here if you do not have
certain mutations in the fat gene from 2
such as those responsible for digestion
is associated with unsaturated fatty
with omega-3 omega-6 acids
then giving up meat and fish increases the risk
development of colon cancer therefore
Kazakhs do not refuse so sharply from
beshbarmaki
[applause]
Thus, the digitization of genomes is
key in the knowledge of the nature of our living
origin and creation
opportunities to improve the quality and
our understanding of this
thesis
grows every day and today
Brittany digitize the genomes of 100 thousand
of their citizens, France is 235 thousand
at least one point four billion
South Korea has a project
digitize the genome of each
Korean on earth
Iceland almost studied all its
population and a list of countries that
set themselves such a national
The task is increasing every year with our
neighbors started to take up the
project of thousands of Russian genomes
technology digitization is improved
every year and its price falls exactly like that
we have such a long-term
strategic national tasks
set
but today we put it together with you
in front of you and tomorrow will put our
government of us only 18 million
Kazakhstan we live on a vast rich
territory resources of the territory we have
As the nation has grandiose plans and
hopes for our future and
each of us seeks to do so
I am sure that we are our research in
perspective
we will close this white spot and our
The state will allow and create
possibilities for digitizing the genome of each
our citizen so that everyone can
get the key to her to read your
genome of its origin so that each
could learn his hereditary deposit
opportunities to open their talents to
each of us could bring our
dream or change it without changing yourself
Thank you for attention
with you was a geneticist maksat
[applause]
[music]
[music]
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