working out of the University of
Pennsylvania dr. June has been
developing a new technology to leverage
the immune systems t-cells to fight and
kill leukemia in mice I’ve been through
a long journey so I was a physician and
then gradually I came a conclusion that
could probably help more people through
my scientific laboratory efforts than
actually seeing people one at a time in
a clinic I tell my family now that my MD
stands for Mouse doctor
the immune system protects you from
outside invasion if a virus bacteria or
fungus slips into your body the immune
system responds with a coordinated
attack that killed the invader and only
the invader leaving your body intact
this is a t-cell this immune cells job
is to kill infected cells before they
cause more damage in theory t-cells can
be extraordinarily potent against
leukemia but there’s one problem
since cancer is effectively part of your
own body the immune system sometimes
ignores these rogue cells allowing the
cancer to spread unchecked jun and his
team have worked tirelessly to find a
way to get the immune system to
recognize and destroy all of the
cancerous cells in the body the therapy
word developing is multidisciplinary it
involves leukemia specialists David
Porter is known around the world for his
treating various kinds of leukemia it
involves immunology expertise viral
vector design expertise and then the
cell culturing expertise the Bruce Avena
knows more about than anyone in the
world
I’m quite sure okay I’m a professor in
cancer gene therapy and I direct the
clinical cell and vaccine production
facility and what we do is to develop
manufacture and test cell and gene
therapies to fight cancer using the
patient’s own immune cells that have
been genetically targeted to cancer a
car t-cell is a t-cell that is
genetically modified in a way that
allows it to see and recognize a cancer
cell a car stands for chimeric antigen
receptor it’s a molecule that is
synthetic we can put it into an immune
cell genetically change the immune cell
to express the car molecule that
function of binding activates the T cell
and it allows it to become active to
become a killer cell and to kill the
leukemia
[Music]
you
[Music]
Pennsylvania dr. June has been
developing a new technology to leverage
the immune systems t-cells to fight and
kill leukemia in mice I’ve been through
a long journey so I was a physician and
then gradually I came a conclusion that
could probably help more people through
my scientific laboratory efforts than
actually seeing people one at a time in
a clinic I tell my family now that my MD
stands for Mouse doctor
the immune system protects you from
outside invasion if a virus bacteria or
fungus slips into your body the immune
system responds with a coordinated
attack that killed the invader and only
the invader leaving your body intact
this is a t-cell this immune cells job
is to kill infected cells before they
cause more damage in theory t-cells can
be extraordinarily potent against
leukemia but there’s one problem
since cancer is effectively part of your
own body the immune system sometimes
ignores these rogue cells allowing the
cancer to spread unchecked jun and his
team have worked tirelessly to find a
way to get the immune system to
recognize and destroy all of the
cancerous cells in the body the therapy
word developing is multidisciplinary it
involves leukemia specialists David
Porter is known around the world for his
treating various kinds of leukemia it
involves immunology expertise viral
vector design expertise and then the
cell culturing expertise the Bruce Avena
knows more about than anyone in the
world
I’m quite sure okay I’m a professor in
cancer gene therapy and I direct the
clinical cell and vaccine production
facility and what we do is to develop
manufacture and test cell and gene
therapies to fight cancer using the
patient’s own immune cells that have
been genetically targeted to cancer a
car t-cell is a t-cell that is
genetically modified in a way that
allows it to see and recognize a cancer
cell a car stands for chimeric antigen
receptor it’s a molecule that is
synthetic we can put it into an immune
cell genetically change the immune cell
to express the car molecule that
function of binding activates the T cell
and it allows it to become active to
become a killer cell and to kill the
leukemia
[Music]
you
[Music]
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