good morning to all tissue croft and
we
ap innovative incubated
but in the era
and that operates in the field of biomedical
in particular it is concerned with studying and
develop innovative products
The soft tissue surgery
This is a requirement that a day
today arises in manner overriding
because the population is aging
and a little as it does for cars
that after years of little need
restyling of replacements of bad parts
functioning and even the human body is a
while a tool with a machine that
time in years and then you wear
need in some cases replacement
and then arises in this context, the
research that deals with the
engineering and regenerative medicine
tissue to support research
tissue engineering
opens a vast field that what
of biomaterials biomaterials are
materials that are used
commonly to study implants
substitutions and accordingly they may be
use materials of different nature
and here you see the slides that are
named the main types of tissues
sorry of materials used for the
Replacement of fabrics we can have
polymeric materials of the metallic type
but today I would like to concentrate for you
a few minutes on the last two types ie
composite materials and materials
biological
these have great affinity we will see
with the title of this of this
tour that unity is strength and
I will try to convince you that indeed
this way of thinking to an even base
solid biomaterials in scientific
general need to have properties
biological and adequate mechanical in
replace the malfunctioning organ
so here you choose the solution
suitable for surgical problem
the use of composite materials in
Reality is something that no man
is back for a moment let’s move from
the biomedical field of surgery but
we think of the mud bricks and
mud bricks are formed
substantially from two types of materials
mud and straw separately
Mud straw have the
features that we would never
think of a solid structure
construct a building a house but
Indeed if we compose them together
we can have structures in which
you can even experience this is a
very primitive type of material
composite
However, it is has the characteristics to
It is considered a composite material
Then research in the field of materials
generally it continued to the present day
ours and so much more that goes on
ie first brick composite materials
mud
Now we have translated in creating
composite materials that are used to
build planes for example very
often in my experience I
happened, however, to observe and to draw
from my observations the conclusions
to arrive at a solution because in
Actually composite materials are
something very present in nature
I give you another example in wood here
see a section of a tree trunk
the wood is a composite material that is
there is a soft matrix made of
lignin there are composed of fibers which
together they create what the structure
a tree trunk the human body does not
also it deviates tissues are
materials composite materials bottom
composites, however, specially designed
to solve biological functions
specific
We remain in the example of the bone tissue
or it is formed by a component
mineral from large to suffered from a
component of fibrous collagen type that
It is actually a little bit matrix
more composite but in order to simplify
we combine these two types of materials and
we get the bone tissue
Bone which in turn can have
different microscopic structures but
which they are the ones we need to
get to the last skeleton I
I talked about it made an example of
composite material in wood and then are
passed another example of a material
Composite bone tissue and I
occurred Pinocchio Pinocchio’s
a wooden puppet
However, without bothering to go back to all
the story of Pinocchio was not
satisfied with his body
his being a Marionette not
It satisfies him goes optimally
in that case it intervened and the fairy
he turned into a child, however, was
a fairy tale in reality what
we can do is try to help
Our finding of Pinocchio
solutions from tissues present
already in nature from then fabrics
Biological our body is made up of
a huge variety of biological tissues
Natural extraordinarily composite
with a rich and extraordinary efficiency
in order to get to biological functions
who guarantee the life and
survival
I think it’s a bit pretentious
think of being able to imitate
a fabric perfectly unless we
we do not use the same fabric in order to
repair the damage that has been present in
our body
and then this is the idea behind
graf tissue graft tissue uses of
Organic materials of the matrices
The decellularized biological takes my
the mobile part and not, however, is limited
this according to the necessity
surgical type of use
surgery that is expected for that
biological matrix to recall and then
say on the surface of the matrix
of organic molecules that help to
example tissue regeneration
or do another example where
necessary to make the surface of
This biological material more
resistant infections that
do is to stick to the surface
of the organic matrix of
these antibiotics referred hearing
speak in a very very very
common, however, this is only a
the possibility that underlies
kraft process which is the mark
the startup of the start-up tv kraft there
tell you a little bit more of how
born and what we have become
graf tissue born straddling 2013
and 2014 so it is not a reality
elderly is a reality very far
young was born in
scope university along with
other guys who worked with me
we started working on fabrics
decellularized and we thought
you could get to produce a
different level then you could bring
to industrial production level
something that at that time we were
making the counter to do this and
I go back to the concept that unity is
power
we soon realized that
you had to give our idea the
Our start up a été joan
different heterogeneity and then it is
He joined the tissue actually
carlo carlo graf giani giani deals
to administer
the assets and finances of
company and therefore ensures that we can
have a serenity
from an administrative point of view, this
because I am a biologist and as a result
I could not come up with another job and
so I kept my identity
Scientific and inside the show dt
Kraft is the Scientific Director of
products and processes that we study
with me there are three other guys
Luke twig and chemical and the boy
who thought in fact the researcher
who thought the process right
beginning and still is his
responsibility to advance
enrichment processes of the matrices
martina ramella and then biotechnologist
with me the portion which has more
scientific and application of
products that we study and again
lately it has run joined marta bald kato
It was instead an engineer engineer
that gave an edge to
Our idea because it is capable of
designing the transfer process
technological
then it is you who is able to say how
You can switch from one process to the counter
in an industrial process
so that’s why the diversity we
It makes strong because in reality each of
us has a different background than ever
liberation that is among us makes
strong enough startups and strong I
But about a year ago I heard the
need to find a team that
could help me to ensure
scientific level of our products
and then at that point I reasoned a bit
backwards instead of leading Italy
I carried out abroad and in Italy
and so I created a scientific board
controlling me and that valid
what we try to
carry out in the laboratory and then together
us are Professor of shovel
university of pittsburgh
pittsburgh
Professor and linking and its
hélène assistant berry and again
University of leeds and still the
Professor Diego Mantovani not Italian
but actually he lives in Canada now as
several years and is a professor
University of Laval in Quebec City
so this is the reality
at this time croft tissue is born
a few years ago it has been strengthened and is
zooming is getting bigger but my
academic nature drives me to
try not to stray too far from
what my training precisely
university and then we created
places doctoral apprenticeship
there is one currently underway with
the universities of Bari and another will
activated next year this time
with the University College of
quebec city doctorates are a bit
particularly apprenticeship means
ow that the student fied and passes
half the time in the lab and half
Time in the company and thus learn
the entire economic administrative part
making real opportunities
create a company and also there will be
Also corporate internships soon
in short, that will be open to students
also not including non-doctorate
one last point I want
tissue graft in fact it is a reality
lucky started recently and is
growing up in a short time, however, we
went to put in a context of
booming market
this you see a curve that comes
to the present day
but there is a forecast of strong
also expanding in the coming decades
so this was a little luck
to be able to have the right idea at the time
quite right
and also this is my thought that
It comes from experience to the point
developed in this field in these
years
I believe that start-ups are
opportunity to create
effects work today often feels
talk about the difficulties in obtaining employment
difficulty for young people
here in my case it was a great
opportunities that allowed me to make
grow a parallel reality to that
university where students and
other children of different
training could find a
use
Thank you
[Applause]
we
ap innovative incubated
but in the era
and that operates in the field of biomedical
in particular it is concerned with studying and
develop innovative products
The soft tissue surgery
This is a requirement that a day
today arises in manner overriding
because the population is aging
and a little as it does for cars
that after years of little need
restyling of replacements of bad parts
functioning and even the human body is a
while a tool with a machine that
time in years and then you wear
need in some cases replacement
and then arises in this context, the
research that deals with the
engineering and regenerative medicine
tissue to support research
tissue engineering
opens a vast field that what
of biomaterials biomaterials are
materials that are used
commonly to study implants
substitutions and accordingly they may be
use materials of different nature
and here you see the slides that are
named the main types of tissues
sorry of materials used for the
Replacement of fabrics we can have
polymeric materials of the metallic type
but today I would like to concentrate for you
a few minutes on the last two types ie
composite materials and materials
biological
these have great affinity we will see
with the title of this of this
tour that unity is strength and
I will try to convince you that indeed
this way of thinking to an even base
solid biomaterials in scientific
general need to have properties
biological and adequate mechanical in
replace the malfunctioning organ
so here you choose the solution
suitable for surgical problem
the use of composite materials in
Reality is something that no man
is back for a moment let’s move from
the biomedical field of surgery but
we think of the mud bricks and
mud bricks are formed
substantially from two types of materials
mud and straw separately
Mud straw have the
features that we would never
think of a solid structure
construct a building a house but
Indeed if we compose them together
we can have structures in which
you can even experience this is a
very primitive type of material
composite
However, it is has the characteristics to
It is considered a composite material
Then research in the field of materials
generally it continued to the present day
ours and so much more that goes on
ie first brick composite materials
mud
Now we have translated in creating
composite materials that are used to
build planes for example very
often in my experience I
happened, however, to observe and to draw
from my observations the conclusions
to arrive at a solution because in
Actually composite materials are
something very present in nature
I give you another example in wood here
see a section of a tree trunk
the wood is a composite material that is
there is a soft matrix made of
lignin there are composed of fibers which
together they create what the structure
a tree trunk the human body does not
also it deviates tissues are
materials composite materials bottom
composites, however, specially designed
to solve biological functions
specific
We remain in the example of the bone tissue
or it is formed by a component
mineral from large to suffered from a
component of fibrous collagen type that
It is actually a little bit matrix
more composite but in order to simplify
we combine these two types of materials and
we get the bone tissue
Bone which in turn can have
different microscopic structures but
which they are the ones we need to
get to the last skeleton I
I talked about it made an example of
composite material in wood and then are
passed another example of a material
Composite bone tissue and I
occurred Pinocchio Pinocchio’s
a wooden puppet
However, without bothering to go back to all
the story of Pinocchio was not
satisfied with his body
his being a Marionette not
It satisfies him goes optimally
in that case it intervened and the fairy
he turned into a child, however, was
a fairy tale in reality what
we can do is try to help
Our finding of Pinocchio
solutions from tissues present
already in nature from then fabrics
Biological our body is made up of
a huge variety of biological tissues
Natural extraordinarily composite
with a rich and extraordinary efficiency
in order to get to biological functions
who guarantee the life and
survival
I think it’s a bit pretentious
think of being able to imitate
a fabric perfectly unless we
we do not use the same fabric in order to
repair the damage that has been present in
our body
and then this is the idea behind
graf tissue graft tissue uses of
Organic materials of the matrices
The decellularized biological takes my
the mobile part and not, however, is limited
this according to the necessity
surgical type of use
surgery that is expected for that
biological matrix to recall and then
say on the surface of the matrix
of organic molecules that help to
example tissue regeneration
or do another example where
necessary to make the surface of
This biological material more
resistant infections that
do is to stick to the surface
of the organic matrix of
these antibiotics referred hearing
speak in a very very very
common, however, this is only a
the possibility that underlies
kraft process which is the mark
the startup of the start-up tv kraft there
tell you a little bit more of how
born and what we have become
graf tissue born straddling 2013
and 2014 so it is not a reality
elderly is a reality very far
young was born in
scope university along with
other guys who worked with me
we started working on fabrics
decellularized and we thought
you could get to produce a
different level then you could bring
to industrial production level
something that at that time we were
making the counter to do this and
I go back to the concept that unity is
power
we soon realized that
you had to give our idea the
Our start up a été joan
different heterogeneity and then it is
He joined the tissue actually
carlo carlo graf giani giani deals
to administer
the assets and finances of
company and therefore ensures that we can
have a serenity
from an administrative point of view, this
because I am a biologist and as a result
I could not come up with another job and
so I kept my identity
Scientific and inside the show dt
Kraft is the Scientific Director of
products and processes that we study
with me there are three other guys
Luke twig and chemical and the boy
who thought in fact the researcher
who thought the process right
beginning and still is his
responsibility to advance
enrichment processes of the matrices
martina ramella and then biotechnologist
with me the portion which has more
scientific and application of
products that we study and again
lately it has run joined marta bald kato
It was instead an engineer engineer
that gave an edge to
Our idea because it is capable of
designing the transfer process
technological
then it is you who is able to say how
You can switch from one process to the counter
in an industrial process
so that’s why the diversity we
It makes strong because in reality each of
us has a different background than ever
liberation that is among us makes
strong enough startups and strong I
But about a year ago I heard the
need to find a team that
could help me to ensure
scientific level of our products
and then at that point I reasoned a bit
backwards instead of leading Italy
I carried out abroad and in Italy
and so I created a scientific board
controlling me and that valid
what we try to
carry out in the laboratory and then together
us are Professor of shovel
university of pittsburgh
pittsburgh
Professor and linking and its
hélène assistant berry and again
University of leeds and still the
Professor Diego Mantovani not Italian
but actually he lives in Canada now as
several years and is a professor
University of Laval in Quebec City
so this is the reality
at this time croft tissue is born
a few years ago it has been strengthened and is
zooming is getting bigger but my
academic nature drives me to
try not to stray too far from
what my training precisely
university and then we created
places doctoral apprenticeship
there is one currently underway with
the universities of Bari and another will
activated next year this time
with the University College of
quebec city doctorates are a bit
particularly apprenticeship means
ow that the student fied and passes
half the time in the lab and half
Time in the company and thus learn
the entire economic administrative part
making real opportunities
create a company and also there will be
Also corporate internships soon
in short, that will be open to students
also not including non-doctorate
one last point I want
tissue graft in fact it is a reality
lucky started recently and is
growing up in a short time, however, we
went to put in a context of
booming market
this you see a curve that comes
to the present day
but there is a forecast of strong
also expanding in the coming decades
so this was a little luck
to be able to have the right idea at the time
quite right
and also this is my thought that
It comes from experience to the point
developed in this field in these
years
I believe that start-ups are
opportunity to create
effects work today often feels
talk about the difficulties in obtaining employment
difficulty for young people
here in my case it was a great
opportunities that allowed me to make
grow a parallel reality to that
university where students and
other children of different
training could find a
use
Thank you
[Applause]
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